医学信息2025，Vol.38Issue(9)：1-7,7.DOI:10.3969/j.issn.1006-1959.2025.09.001
基于生物信息学的阿尔兹海默病线粒体相关Hub基因的筛选
Screening of Mitochondrial-related Hub Genes in Alzheimer's Disease Based on Bioinformatics
李晓松 1黄霄 1张亚洲 1李瑞 1李寅臻 1王奎1
作者信息
- 1. 石河子大学医学院预防医学系,新疆 石河子 832000
- 折叠
摘要
Abstract
Objective To screen mitochondrial hub genes associated with Alzheimer's disease by bioinformatics analysis and analyze their functions.Methods The Alzheimer's disease gene chip dataset was downloaded from the GEO database of the National Center for Biotechnology Information in the United States.The hub genes of Alzheimer's disease were screened through differential expression analysis and weighted gene co-expression network analysis.The mitochondrial related genes were obtained from the MitoCarta 3.0 database and intersected with the aforementioned hub genes.The intersection genes were enriched and analyzed,and a protein interaction network was constructed using the String database.The results were imported into Cytoscape software,and the top 6 genes ranked in Degree were screened using the MCC algorithm.Results A total of 380 down-regulated genes and 279 up-regulated genes were screened by differential expression analysis.A total of 1073 genes were screened by weighted gene co-expression network analysis,and 15 mitochondrial-related genes were obtained by intersection with mitochondrial genes.GO enrichment analysis showed that it was mainly involved in biological processes such as changes in mitochondrial morphology,replication of mitochondrial genome,synthesis of new mitochondrial components,and mitochondrial material transport.KEGG pathway enrichment analysis showed that it was mainly enriched in Parkinson's disease,Huntington's disease,propionic acid metabolism and cholesterol metabolism.Finally,six mitochondrial hub genes related to Alzheimer's disease were screened by Cytoscape software:VDAC1,TOMM20,CISD1,OPA1,NDUFAB1,TSPO.Conclusion Through the Alzheimer's disease gene chip data set and combined with a variety of bioinformatics analysis methods,six mitochondrial hub genes have identified,which can provide a theoretical basis for the role of mitochondrial dysfunction in Alzheimer's disease.关键词
生物信息学/阿尔兹海默病/线粒体/枢纽基因Key words
Bioinformatics/Alzheimer's disease/Mitochondria/Hub genes分类
临床医学引用本文复制引用
李晓松,黄霄,张亚洲,李瑞,李寅臻,王奎..基于生物信息学的阿尔兹海默病线粒体相关Hub基因的筛选[J].医学信息,2025,38(9):1-7,7.
