医学信息2025，Vol.38Issue(9)：42-49,8.DOI:10.3969/j.issn.1006-1959.2025.09.007
基于文献挖掘的慢性盆腔炎动物模型应用分析
Application Analysis of Chronic Pelvic Inflammatory Disease Animal Model Based on Literature Mining
李苒 1杨凤娟 1喻志丽 1轩婉璐 1李至慧 1介嘉悦 1张晓静 1何群力1
作者信息
- 1. 郑州医药健康职业学院基础医学部,河南 新密 450046
- 折叠
摘要
Abstract
Objective To provide a methodological reference for improving the success rate of modeling and evaluating the effectiveness of the tested drugs by studying the modeling method and various examination index elements of animal models of chronic pelvic inflammatory disease.Methods With"chronic pelvic inflammatory disease"and"animal model"as the key words,databases such as CNKI,Wanfang,Pubmed and Web of Science(WoS)were searched.The types of experimental animals,modeling methods,modeling time,administration period,and detection indicators were collected to establish and process the database,and the commonly used modeling methods,key factors for modeling,and model characteristics were summarized.Results A total of 133 articles were included,of which 180-240 g female SD rats were the most widely used experimental animals.The most commonly used modeling method was bilateral intrauterine injection of 25%phenol mucilage.The modeling time of mixed bacterial infection method and chemical burning method was mostly 7 days,the administration cycle of mixed bacterial infection method was mostly 21 days,the administration cycle of chemical burning method was mostly 14 days,the modeling time of foreign body placement method was 14 days,and the administration cycle was 21 days.The high-frequency detection indexes were HE staining to observe uterine tissue pathology and serum TNF-α,IL-6,IL-1β levels,etc.,and the clustering could be divided into 8 categories.Conclusion The existing animal models of chronic pelvic inflammatory disease are mostly single-factor models,and the combination of model detection indicators and TCM symptoms is low.A more comprehensive CPID model of integrated traditional Chinese and Western medicine should be established,which is conducive to the scientific development of subsequent research on efficacy or mechanism.关键词
慢性盆腔炎/动物模型/数据挖掘/应用分析/生化指标Key words
Chornic pelvic inflmamatory disease/Animal model/Data mining/Application analysis/Biochemical index分类
中医学引用本文复制引用
李苒,杨凤娟,喻志丽,轩婉璐,李至慧,介嘉悦,张晓静,何群力..基于文献挖掘的慢性盆腔炎动物模型应用分析[J].医学信息,2025,38(9):42-49,8.
