畜牧兽医学报2025，Vol.56Issue(4)：1484-1493,10.DOI:10.11843/j.issn.0366-6964.2025.04.002
哺乳动物卵泡发育阶段颗粒细胞增殖与分化的研究进展
Research Progress on the Proliferation and Differentiation of Granulosa Cells at Various Follicular Development Stages in Mammal
摘要
Abstract
Spermatogenesis,oogenesis,and the development of a fertilized egg,are all crucial in mammalian reproduction.Currently,there is no shortage of studies on the maturation and devel-opment of mammalian oocytes,but the role of granulosa cells in the development of oocytes re-mains to be explored in depth.In female mammals,early ovarian granulosa cells are developed from the ovarian reticulum and ovarian epidermal cells;thereafter,the precursor granulosa cell stage surrounds the oocyte,providing nutrients and communicates information for the oocyte through gap junctions,and regulating oocyte maturation by relying on the regulation of reproduc-tion hormones(such as AMH,FSH,and LH).In this paper,the origin of mammalian ovarian granulosa cells,the differentiation of granulosa cells at each stage of follicle development,and their functional mechanism during oocyte maturation were reviewed in order to provide help for the further study of the biological functions of mammalian ovarian granulosa cells,and provide optimization ideas for the in vitro oocyte maturation culture system.关键词
卵巢/颗粒细胞/卵母细胞/哺乳动物/增殖与分化Key words
ovary/granulosa cells/oocytes/mammals/proliferation and differentiation分类
农业科技引用本文复制引用
郭妍岩,郭晓飞,张羽欣,陆瑞,李玉鹏,陈龙宾,张金龙,姚大为,阮维斌,张效生..哺乳动物卵泡发育阶段颗粒细胞增殖与分化的研究进展[J].畜牧兽医学报,2025,56(4):1484-1493,10.基金项目
天津市自然科学基金(23JCYBJC00260) （23JCYBJC00260）
吉林省青年成长科技项目(20230508122RC) （20230508122RC）
天津市重点研发计划(23YFZCSN00170) （23YFZCSN00170）
畜禽生物育种全国重点实验室开放课题(2024SKLAB6-11 （）
2024SKLAB6-4) （）
天津市财政预算项目(24YDTPJC00290,24YDTPJC00480) （24YDTPJC00290,24YDTPJC00480）
天津市农业科学院种业创新项目(2024ZYCX012) （2024ZYCX012）
