现代医药卫生2025，Vol.41Issue(4)：840-845,6.DOI:10.3969/j.issn.1009-5519.2025.04.005
基于生物信息学分析骨膜蛋白在胃癌中的临床意义及作用机制
Clinical significance and mechanism of periostin in gastric cancer based on bioinformatics analysis
摘要
Abstract
Objective To analyze the clinical significance and mechanism of periostin(POSTN)in gas-tric cancer based on bioinformatics methods.Methods The expression of POSTN gene in pan-cancer and gas-tric cancer was analyzed by UALCAN database,and the gene changes of POSTN in pan-cancer and gastric cancer were studied by cBioPortal database.The Human Protein Atlas database was used to compare the differences in the expression of POSTN gene-encoded proteins in gastric cancer tissues and non-cancerous gas-tric tissues.The relationship between POSTN expression level and survival time of gastric cancer patients was obtained by Kaplan-Meier Plotter database.The STRING database was used to construct a network of POSTN-related proteins.Results POSTN gene was widely expressed in pan-cancer.The expression levels of POSTN gene and protein in gastric cancer tissues were significantly higher than those in normal gastric tissues(P＜0.05).The results of survival analysis showed that the survival time of gastric cancer patients with high expression of POSTN was significantly shorter than that of patients with low expression of POSTN,and the difference was statistically significant(P＜0.05).In addition,the STRING database showed that the proteins interacting with POSTN mainly include FN1,BMP1,COL3A1,NOTCH1,COL1A2,etc.,which are mainly re-lated to collagen fiber construction,extracellular matrix construction,vascular development,tissue develop-ment and other processes.Conclusion POSTN is highly expressed in gastric cancer and negatively correlated with prognosis,suggesting that POSTN may be used as a new molecular marker for the diagnosis and progno-sis of gastric cancer.关键词
POSTN/胃癌/生物信息学/作用机制Key words
POSTN/Gastric cancer/Bioinformatics/Mechanism分类
医药卫生引用本文复制引用
陈雨濛,宣丽颖,付卓..基于生物信息学分析骨膜蛋白在胃癌中的临床意义及作用机制[J].现代医药卫生,2025,41(4):840-845,6.基金项目
内蒙古自治区自然科学基金项目(2020MS08031) （2020MS08031）
内蒙古民族大学科研启动基金项目(KYQD23014). （KYQD23014）
