畜牧兽医学报2025，Vol.56Issue(4)：1527-1539,13.DOI:10.11843/j.issn.0366-6964.2025.04.006
环境富集对哺乳期母子分离子代行为异常的缓解及其分子机制研究进展
Reversal Effect of Environmental Enrichment on Behavioral Abnormalities in Lactation Maternal Separation Offspring and Its Molecular Mechanism
摘要
Abstract
Adverse early life experiences affect the developing nervous system,and shape the off-spring's adult social behavior pattern.Maternal separation is an early life stress that lactating off-spring often face,which has a lasting impact on their psychological and physiological development and can lead to neuroendocrine system disorders in offspring,and increases the risk of abnormal behavior and mental illness in the offspring's adult.Environmental enrichment is a therapeutic strategy used to improve the quality of life of captive animals,stimulate animal emotional expres-sion,and reverse neurological damage or behavioral abnormalities in early stressed animals.The behavioral plasticity of offspring induced by early stress can be restored by environmental enrich-ment intervention in later life(adolescence or adulthood).Neurobiological changes and epigenetic modification are the main molecular mechanisms by which environmental enrichment reverses the abnormal behavior of early stressed offspring.Therefore,this paper reviews the abnormal behav-ior of offspring caused by maternal separation,the effects of environmental enrichment on allevi-ating the abnormal behavior of maternal separation,and the molecular mechanisms involved in regulating environmental enrichment effects.In order to provide effective intervention strategies for early life stress offspring abnormal behavior,and provide scientific basis for improving the welfare level of captive animals.关键词
母子分离/行为异常/环境富集/逆转效应/分子机制Key words
maternal separation/abnormal behavior/environmental enrichment/reversal effect/molecular mechanism分类
农业科技引用本文复制引用
王慧,王悦尚,胡希怡,韩成全,李富宽,杨燕,吕慎金..环境富集对哺乳期母子分离子代行为异常的缓解及其分子机制研究进展[J].畜牧兽医学报,2025,56(4):1527-1539,13.基金项目
国家自然科学基金项目(31802105 （）
32372939) （）
2024年山东省自然科学基金面上项目(ZR2023MC032) （ZR2023MC032）
山东省牧草产业技术体系临沂综合试验站(SDAIT-23-08) （SDAIT-23-08）
山东省羊产业技术体系临沂综合试验站(SDAIT-10-13) （SDAIT-10-13）
