心脑血管病防治2025，Vol.25Issue(3)：26-29,38,5.DOI:10.3969/j.issn.1009-816x.2025.03.006
血清可溶性骨髓细胞样转录因子-1、甲壳质酶蛋白-40水平对动脉瘤性蛛网膜下腔出血并发迟发性脑缺血患者诊断及预后的评估价值
崔茜 1杨丽梅 2李延玲1
作者信息
- 1. 056001 河北省邯郸市人民医院肿瘤科
- 2. 056001 河北省邯郸市中心医院重症医学科
- 折叠
摘要
Abstract
Objective To investigate the serum levels of the serum soluble triggering receptor expressed on myeloid cell like transcription factor-1(sTLT-1)and chitinase protein-40(YKL-40)in patients with delayed cerebral ischemia(DCI)after aneurysmal subarachnoid hemorrhage(aSAH),and to assess their diagnostic and prognostic value.Methods A total of 84 patients with aSAH complicated by DCI admitted to Handan People's Hospital from June 2019 to June 2023 were selected as the DCI group,and 94 aSAH patients without DCI during the same period were selected as the non-DCI group.Clinical data and serum levels of sTLT-1 and YKL-40 were compared between the two groups.According to the prognosis of DCI patients,they were further divided into a good prognosis group(44 cases)and a poor prognosis group(40 cases).Serum levels of sTLT-1 and YKL-40 were compared among patients with different prognosis.Multivariate Logistic regression analysis was applied to identify influence factors for DCI in aSAH patients.ROC curves were used to analyze the diagnostic and prognostic value of serum sTLT-1 and YKL-40 levels in aSAH patients with DCI.Results The proportions of patients with Hunt-Hess grade 3 or higher and Fisher grade 3 or higher,the serum levels of sTLT-1 and YKL-40 were higher in the DCI group than those in the non-DCI group(t=4.840,10.555,7.117,6.409;P＜0.05).Multivariate Logistic regression analysis showed that sTLT-1 and YKL-40 were risk factors for DCI in patients with aSAH(OR=4.972,4.854;P＜0.05).The serum levels of sTLT-1 and YKL-40 were higher in the poor prognosis group than those in the good prognosis group(t=7.079,5.486;P＜0.05).The AUC values for assessing DCI in aSAH patients were 0.797 for sTLT-1 and 0.766 for YKL-40,while the combined assessment of both markers yielded an AUC of 0.905,which was higher than those of individual markers(Z=2.612,3.295;P＜0.05).The AUC values for predicting poor prognosis in aSAH patients with DCI were 0.764 for sTLT-1 and 0.805 for YKL-40,with a combined AUC of 0.913,which was also higher than those of individual markers(Z=2.503,2.116;P＜0.05).Conclusion Serum levels of sTLT-1 and YKL-40 have diagnostic and prognostic value in patients with aSAH complicated by DCI.关键词
动脉瘤性蛛网膜下腔出血/迟发性脑缺血/可溶性骨髓细胞样转录因子-1/甲壳质酶蛋白-40Key words
Aneurysmal subarachnoid hemorrhage/Delayed cerebral ischemia/Soluble triggering receptor expressed on myeloid cell-like transcription factor-1/Chitinase protein-40引用本文复制引用
崔茜,杨丽梅,李延玲..血清可溶性骨髓细胞样转录因子-1、甲壳质酶蛋白-40水平对动脉瘤性蛛网膜下腔出血并发迟发性脑缺血患者诊断及预后的评估价值[J].心脑血管病防治,2025,25(3):26-29,38,5.
