心脑血管病防治2025，Vol.25Issue(3)：30-33,55,5.DOI:10.3969/j.issn.1009-816x.2025.03.007
血清可溶性白细胞分化抗原14亚型、激活素A水平与慢性心力衰竭合并肺部感染患者肺部感染程度的相关性
Correlation between serum soluble cluster of differentiation-subtype 14,activin A levels and severity of pulmonary infection in patients with chronic heart failure combined with pulmonary infection
摘要
Abstract
Objective To analyze the correlation between serum soluble cluster of differentiation-subtype 14(sCD14-ST),activin A(ACTA)levels and the severity of pulmonary infection in patients with chronic heart failure combined with pulmonary infection(CHF-PI).Methods A total of 120 patients with CHF-PI admitted to Guang'anmen Hospital,Baoding Hospital,Chinese Academy of Chinese Medicine Sciences from June 2022 to February 2024 were collected.They were divided into a mild group(42 cases)and a severe group(78 cases)according to pulmonary infection severity.Enzyme-linked immunosorbent assay(ELISA)was applied to detect serum sCD14-ST and ACTA levels,and clinical data of CHF-PI patients was collected and analyzed.Multivariate Logistic regression was applied to analyze the influencing factors for severe pulmonary infections in CHF-PI patients.Receiver operating characteristic(ROC)curves were plotted to analyze the diagnostic value of serum sCD14-ST and ACTA for pulmonary infection severity in CHF-PI patients.Results Compared with the mild group,the serum sCD14-ST and ACTA levels in the severe group were obviously increased(t=8.851,10.663;P＜0.05).There were statistically significant differences in terms of hypertension prevalence and levels of left ventricular ejection fraction(LVEF),C-reactive protein(CRP),and N-terminal pro brain natriuretic peptide(NT-proBNP)between the two groups(t/x2=4.766,3.175,8.107,9.271;P＜0.05).Multivariate Logistic regression analysis showed that LVEF was a protective factor against severe pulmonary infections in CHF-PI patients,while hypertension and levels of CRP,NT-proBNP,sCD14-ST,and ACTA were all risk factors(OR=0.588,1.234,1.325,1.541,2.015,1.874;P＜0.05).The areas under the curve(AUCs)for serum sCD14-ST,ACTA,and their combination in diagnosing pulmonary infection severity in patients with CHF-PI were 0.842,0.830,and 0.901,respectively,with combined detection outperforming individual markers(Z=2.389,2.339;P＜0.05).Conclusion Serum sCD14-ST and ACTA levels correlate with pulmonary infection severity in CHF-PI patients and demonstrate good diagnostic value for pulmonary infection.关键词
慢性心力衰竭/肺部感染/可溶性白细胞分化抗原14亚型/激活素AKey words
Chronic heart failure/Pulmonary infection/Soluble cluster of differentiation-subtype 14/Activin A引用本文复制引用
翟颖,马振兴,杨慧敏,杨红艳,陈英茹..血清可溶性白细胞分化抗原14亚型、激活素A水平与慢性心力衰竭合并肺部感染患者肺部感染程度的相关性[J].心脑血管病防治,2025,25(3):30-33,55,5.基金项目
保定市科技计划项目(2341ZF296) （2341ZF296）
