眼科新进展2025，Vol.45Issue(5)：369-374,6.DOI:10.13389/j.cnki.rao.2025.0065
糖尿病性黄斑水肿抗VEGF治疗前后视网膜内液体积量化与视觉功能相关性
Quantification of intraretinal fluid volume and its correlation with visual function before and after anti-VEGF treatment in diabetic macular edema
摘要
Abstract
Objective To quantify the intraretinal fluid(IRF)volume in patients with diabetic macular edema(DME)using a deep learning-based three-dimensional segmentation model and to investigate the relationship of IRF volume with visual function and retinal biomarkers based on optical coherence tomography(OCT).Methods A total of 37 pa-tients(42 eyes)with DME who received treatment in the Ophthalmology Department of Sichuan Provincial People's Hospi-tal from July 2022 to September 2024 were prospectively included in this study.A three-dimensional segmentation model was used to automatically quantify the IRF volume within a 6 mm × 6 mm OCT scan at baseline and at the last follow-up.The correlation of visual acuity with IRF volume,central subfield thickness(CST),disorganization of the retinal inner lay-ers(DRIL),hyperreflective foci(HRF),external limiting membrane(ELM),ellipsoid zone(EZ),and vitreomacular in-terface abnormality(VMIA)was analyzed at baseline and the last follow-up.Additionally,the correlation of IRF volume with CST,DRIL,HRF,ELM,EZ,and VMIA was analyzed at both time points.Furthermore,the correlation of the visual acuity at the last follow-up with the IRF volume,CST,DRIL,HRF,ELM,EZ,and VMIA at baseline was analyzed.Results Compared with the baseline value,patients exhibited a significant increase in the best corrected visual acuity(BCVA)(logMAR),a significant decrease in the IRF volume and CST,a significant reduction in the HRF,a significant re-covery in the DRIL,ELM,and EZ(all P＜0.05),and no significant changes in the VMIA(P=1.000)at the last follow-up.At baseline,the BCVA was negatively correlated with the IRF volume,CST,DRIL,and HRF,but positively correlated with the ELM and EZ(all P＜0.05);there was no correlation between the BCVA and VMIA(P=0.069).At the last follow-up,the BCVA was negatively correlated with the DRIL,HRF,and VMIA,but positively correlated with the ELM and EZ(all P＜0.01);the BCVA did not correlate with the IRF volume and CST(P=0.419 and 0.994).At baseline,the IRF volume was positively correlated with the CST(P＜0.001)but negatively correlated with the ELM and EZ(P＜0.01);the IRF vol-ume did not correlate with the DRIL,HRF,and VMIA(all P＞0.05).At the last follow-up,the IRF volume was positively correlated with the CST and HRF(all P＜0.01);however,it was not correlated with the DRIL,ELM,EZ,and VMIA(all P＞0.05).The BCVA at the last follow-up was positively correlated with the BCVA,ELM,and EZ at baseline,but negative-ly correlated with the IRF volume,CST,DRIL,HRF,and VMIA at baseline(all P＜0.05).Conclusion The baseline IRF volume in DME patients is an important influencing factor of visual acuity at baseline and the last follow-up.Hence,the IRF volume may serve as a potential biomarker in the management of DME.关键词
糖尿病性黄斑水肿/三维分割/IRF体积/OCT生物标志物/最佳矫正视力Key words
diabetic macular edema/three-dimensional segmentation/IRF volume/OCT biomarkers/best corrected visual acuity分类
临床医学引用本文复制引用
刘逸,沈亚丹,郭楚云,陈丽,李杰,倪光明,钟捷..糖尿病性黄斑水肿抗VEGF治疗前后视网膜内液体积量化与视觉功能相关性[J].眼科新进展,2025,45(5):369-374,6.基金项目
国家自然科学基金项目(编号:62376173,61905036) （编号:62376173,61905036）
四川省卫健委重点研发项目(编号:ZH2024-201) （编号:ZH2024-201）
北京医卫健康公益基金会医学科学研究项目(编号:YWJKJHKYJJ-KHE2405) （编号:YWJKJHKYJJ-KHE2405）
