现代医药卫生2025，Vol.41Issue(4)：858-860,3.DOI:10.3969/j.issn.1009-5519.2025.04.008
多奈哌齐对慢性酒精中毒性脑病认知功能障碍的影响
Effect of Donepezil on cognitive impairment in chronic alcoholic encephalopathy
摘要
Abstract
Objective To investigate the effect of Donepezil on cognitive impairment in patients with chronic alcoholic encephalopathy.Methods A total of 60 patients diagnosed with chronic alcoholic encepha-lopathy,admitted to our hospital from January 2023 to June 2024,were selected and divided into the control group and the treatment group,with 30 patients in each group.The control group received alcohol cessation combined with vitamin B1 intervention for one month,while the treatment group received Donepezil hydro-chloride(5 mg)orally once a night in addition to the intervention given to the control group,for one month.Both groups were assessed using the Mini-Mental State Examination(MMSE)and Activities of Daily Living scale(ADL)before and one month after treatment.Results There was no significant difference in ADL scores between the two groups before treatment(P＞0.05).After treatment,the ADL score in the treatment group[(22.73±2.98)points]was significantly lower than that of the control group[(26.17±4.17)points],with a statistically significant difference in the change in scores between the two groups(P＜0.05).There was no significant difference in MMSE scores between the two groups before treatment(P＞0.05).After treatment,the MMSE score in the treatment group[(26.40±3.00)points]was significantly higher than that of the con-trol group[(22.40±3.76)points],with a statistically significant difference in the change in scores between the two groups(P＜0.001).The incidence of adverse reactions after treatment was similar between the two groups(P＞0.05).Conclusion Donepezil can improve the cognitive function of chronic alcoholic encephalopa-thy.关键词
多奈哌齐/慢性酒精中毒性脑病/认知功能障碍/简易精神状态量表/日常生活能力量表Key words
Donepezil/Chronic alcoholic encephalopathy/Cognitive impairment/Mini-Mental State Examination/Activities of daily living scale分类
医药卫生引用本文复制引用
彭梅,包太成,张兴丽,肖青焕..多奈哌齐对慢性酒精中毒性脑病认知功能障碍的影响[J].现代医药卫生,2025,41(4):858-860,3.基金项目
遵义市科技计划项目(遵市科合HZ字[2022]461号). （遵市科合HZ字[2022]461号）
