畜牧兽医学报2025，Vol.56Issue(4)：1594-1607,14.DOI:10.11843/j.issn.0366-6964.2025.04.011
金黄色葡萄球菌毒力调控及减毒药物研究进展
Research Progress on Virulence Regulation and Antivirulence Drugs of Staphylococcus aureus
摘要
Abstract
Staphylococcus aureus(S.aureus)is an important zoonotic pathogen capable of cau-sing various infectious diseases,posing a serious threat to human and animal health.It produces multiple virulence factors such as toxins,adhesion proteins,and immune evasion factors,and possesses a complex regulatory network for virulence.Due to issues like antibiotic resistance faced by traditional antibiotic treatments,the development of novel drugs aimed at reducing or e-liminating the virulence of S.aureus has become a new direction in antimicrobial drug develop-ment.This article provides a comprehensive review of the latest advances in the regulation of S.aureus virulence and the development of antivirulence drugs,offering a reference and scientific basis for understanding the pathogenic mechanisms of S.aureus and further research on antiviru-lence drugs.关键词
金黄色葡萄球菌/毒力/调控机制/减毒药物Key words
Staphylococcus aureus/virulence/regulatory mechanisms/antivirulence drugs分类
农业科技引用本文复制引用
吉星,李俊,王冉,何涛..金黄色葡萄球菌毒力调控及减毒药物研究进展[J].畜牧兽医学报,2025,56(4):1594-1607,14.基金项目
江苏省自然科学基金项目(BK20220746) （BK20220746）
