现代医药卫生2025，Vol.41Issue(4)：874-877,4.DOI:10.3969/j.issn.1009-5519.2025.04.012
老年偏头痛患者血清MnSOD、hs-CRP水平与认知功能的关系研究
The relationship between serum MnSOD,hs-CRP levels and cognitive function in elderly patients with migraine
代雪莲 1刘海林 1叶静纳1
作者信息
- 1. 郑州大学附属洛阳中心医院神经内科二病区,河南 洛阳 471000
- 折叠
摘要
Abstract
Objective To study the relationship between serum manganese superoxide dismutase(Mn-SOD),high-sensitivity C-reactive protein(hs-CRP)levels and cognitive function in elderly patients with mi-graine.Methods A total of 118 elderly migrainepatients admitted to the hospital from January 2023 to Janu-ary 2024 were selected for the experiment.According to the Montreal Cognitive Assessment(MoCA)score,All patients were divided into normal cognitive function group(MoCA≥26 points,68 cases)and cognitive dys-function group(MoCA＜26 points,50 cases).The baseline data of the two groups were compared.The levels of serum MnSOD and hs-CRP were detected in the two groups.Logistic regression analysis was used to ana-lyze the risk factors affecting cognitive function in elderly patients with migraine.The value of serum MnSOD and hs-CRP levels in predicting cognitive dysfunction in elderly patients with migraine was evaluated by receiver operator characte ristic(ROC)curve.Results The serum MnSOD level in the cognitive dysfunction group was lower than that in the normal cognitive function group[(6.33±1.25)U/mL vs.(12.35±2.33)U/mL],and the hs-CRP was higher than that in the normal cognitive function group[(6.82±1.65)mg/L vs.(3.15±1.02)mg/L],the differences were statistically significant(P＜0.05).Multivariate logistic regression analysis confirmed that serum MnSOD＜7.410 U/mL and hs-CRP＞4.032 mg/L were risk factors affecting cognitive function in elderly patients with migraine(P＜0.05).ROC curve analysis confirmed that serum MnSOD and hs-CRP could be used to predict cognitive dysfunction in elderly patients with migraine,and the area under the curve was 0.980 and 0.973,respectively(P＜0.05).Conclusion The decrease of serum MnSOD level and the increase of hs-CRP level can be used as an important reference index to evaluate cognitive dysfunction in elder-ly patients with migraine.关键词
老年/偏头痛/锰超氧化物歧化酶/超敏C反应蛋白/认知功能Key words
Elderly/Migraine/Manganese superoxide dismutase/High-sensitivity C-reactive protein/Cognitive function分类
医药卫生引用本文复制引用
代雪莲,刘海林,叶静纳..老年偏头痛患者血清MnSOD、hs-CRP水平与认知功能的关系研究[J].现代医药卫生,2025,41(4):874-877,4.
