眼科新进展2025，Vol.45Issue(5)：403-409,7.DOI:10.13389/j.cnki.rao.2025.0071
多组学研究在糖尿病视网膜病变发病机制中的应用研究进展
Research advances in the application of multi-omics studies in the pathogene-sis of diabetic retinopathy
摘要
Abstract
Diabetic retinopathy(DR),as one of the most common microvascular complications in patients with diabe-tes mellitus(DM),has a complex and multifaceted etiology that involves multiple factors.The unique characterization of DR in genomics,epigenomics,transcriptomics,proteomics,and metabolomics has opened new avenues for the exploration and development of novel therapeutic strategies for this disease.However,the inherent limitation of single-omics approa-ches is that they can only analyze the biological and molecular mechanisms underlying the disease from a single dimension,which makes it difficult to comprehensively capture the complex nature of DR.With the rapid advancement of high-throughput sequencing technology,multi-omics joint analysis combines the advantages of different histological techniques and can explore the pathogenesis of DR from multiple dimensions and levels.This paper aims to comprehensively review the latest progress of multi-omics technologies in revealing the pathogenesis of DR and its complex molecular mechanisms and thoroughly explore the new opportunities,current challenges,and future development prospects of multi-omics tech-nologies for DR research.关键词
糖尿病视网膜病变/基因组学/转录组学/蛋白质组学/代谢组学/多组学技术整合Key words
diabetic retinopathy/genomics/transcriptomics/proteomics/metabolomics/multi-omics technology in-tegration分类
医药卫生引用本文复制引用
刘晓静,张越,许衍辉,陈志敏..多组学研究在糖尿病视网膜病变发病机制中的应用研究进展[J].眼科新进展,2025,45(5):403-409,7.基金项目
河北省医学科学研究课题计划项目(编号:20250250) （编号:20250250）
