摘要
Abstract
Objective To explore the value of carbon dioxide binding capacity(CO2 CP)combined with serum β-hydroxybutyrate(β-HB)and lactic acid(LAC)in the diagnosis and assessment of diabetic ketoacido-sis.Methods A total of 70 patients with diabetic ketoacidosis and 70 patients with simple diabetes mellitus(without ketoacidosis)treated in the hospital from August 2020 to February 2024 were selected and divided into diabetic ketoacidosis and diabetes mellitus groups,and 70 healthy people who were admitted for physical examination during the same period of time were recruited as the control group.According to the severity of the disease,the patients with diabetic ketoacidosis were divided into mild(23 cases),moderate(25 cases)and severe(22 cases)groups.The levels of CO2CP,β-HB and LAC were compared in each group,and the diabetes mellitus group was used as the control group.The diagnostic value of CO2CP,β-HB and LAC for diabetic ke-toacidosis were evaluated by receiver operator characteristics(ROC)curves,and the joint predictive risk of each index was constructed by logistic binary regression fitting,and the area under the curve(AUC)of each in-dex and the joint were compared.Pearson correlation coefficient was used to analyze the correlation between each index and arterial blood pH.Results CO2CP,β-HB and LAC single indexes all had diagnostic value for diabetic ketoacidosis,with AUC of 0.729,0.721,0.717,respectively,and the combined diagnostic AUC was 0.856,which was higher than that of the single indexes(Z=3.350,3.305,3.158,P＜0.05).Comparison of CO2CP,β-HB and LAC levels in diabetic ketoacidosis patients with different disease severity showed statisti-cally significant differences(P＜0.05);among them,CO2CP level:mild group＞moderate group＞severe group,and β-HB and LAC levels:mild group＜moderate group＜severe group.Pearson correlation analysis showed that CO2CP,β-HB and LAC levels in patients with diabetic ketoacidosis were negatively correlated with arterial blood pH,respectively(r=-0.751,-0.584,-0.688,P＜0.05).Conclusion CO2CP,β-HB and LAC have relatively high diagnostic value for diabetic ketoacidosis and can also be used to assess the se-verity of the condition.关键词
糖尿病酮症酸中毒/二氧化碳结合力/β-羟丁酸/乳酸/诊断价值/病情评估Key words
Diabetic ketoacidosis/Carbon dioxide binding capacity/β-hydroxybutyric acid/Lactic acid/Diagnostic value/Condition assessment分类
医药卫生
