临床研究2025，Vol.33Issue(5)：48-51,4.DOI:10.12385/j.issn.2096-1278(2025)05-0048-04
肾功能亢进对万古霉素血药谷浓度的影响
The Impact of Hyperrenal Function on Serum Vancomycin Trough Concentrations
摘要
Abstract
Objective To observe the effect of hyperrenal function on serum vancomycin trough concentrations.Methods indicating normal renal function,served as the control group.The two groups were compared in terms of vancomycin usage duration,serum vancomycin trough concentrations,the proportion of concentration distribution ranges,and inflammatory biomarkers—including C-reactive protein(CRP),white blood cell count(WBC),procalcitonin(PCT),and neutrophil count(NEUT)—before and after medication.Results The experimental group had a shorter duration of vancomycin use than the control group,but this difference was not statistically significant(P＞0.05).The serum vancomycin trough concentration in the experimental group was lower than that in the control group,with a statistically significant difference(P＜0.05).The proportions of concentrations＜10 mg/L and＞20 mg/L in both groups showed statistically significant differences(P＜0.05).After medication,levels of CRP and PCT in the experimental group were higher than those in the control group,with significant differences(P＜0.05).The levels of WBC and NEUT showed no statistically significant difference compared to the control group(P＞0.05).Conclusion Hyperrenal function can reduce serum vancomycin trough concentration,thereby impairing infection control and decreasing therapeutic efficacy.It is recommended that clinicians conduct early screening and diagnosis of renal function,adjust vancomycin dosing regimens accordingly,to improve treatment outcomes and reduce adverse reactions.关键词
万古霉素/肾功能亢进/血药浓度/药物监测Key words
Vancomycin/Hyperrenal Function/Serum Concentration/Therapeutic Drug Monitoring分类
医药卫生引用本文复制引用
方昊,付凯,王永辉..肾功能亢进对万古霉素血药谷浓度的影响[J].临床研究,2025,33(5):48-51,4.基金项目
基于拉曼增强基底的万古霉素血药浓度检测系统构建与临床用药指导(222102310272). （222102310272）
