中国免疫学杂志2025，Vol.41Issue(5)：1025-1029,5.DOI:10.3969/j.issn.1000-484X.2025.05.001
肺炎克雷伯菌与炎症性肠病的研究进展
Research progress of Klebsiella pneumoniae and inflammatory bowel disease
摘要
Abstract
Inflammatory bowel diseases(IBD)are a group of chronic non-specific intestinal inflammatory diseases,the etiology of which is not completely clear.Recent studies have found that the intestinal infection rate of Klebsiella pneumoniae in IBD patients is significantly higher than that in healthy people.Animal experiments have also shown that the intestinal colonization of Klebsiella pneu-moniae aggravates the development of IBD.With the continuous evolution of pathogens,Klebsiella pneumoniae with multi-drug resis-tant characteristics has been widely spread around the world,which makes it difficult to effectively eliminate colonized Klebsiella pneu-moniae by conventional antibiotic treatment,and may cause related disease risks.At present,the understanding of how Klebsiella pneumoniae affects the intestinal environment to promote or aggravate IBD is still very limited.It is of great significance to understand the mechanism of Klebsiella pneumoniae affecting the occurrence and development of IBD and to explore potential therapeutic targets.This review summarizes the association between Klebsiella pneumoniae and IBD and the possible mechanism of Klebsiella pneumoniae affecting the development of IBD,in order to provide clues for further research.关键词
炎症性肠病/肺炎克雷伯菌/肠道免疫调控/肠道微生物Key words
Inflammatory bowel diseases/Klebsiella pneumoniae/Intestinal immunoregulation/Gut microbiota分类
基础医学引用本文复制引用
郑嘉玲,王青青..肺炎克雷伯菌与炎症性肠病的研究进展[J].中国免疫学杂志,2025,41(5):1025-1029,5.基金项目
国家重点研发计划政府间国际科技合作专项(2022YFE0102100) （2022YFE0102100）
国家自然科学基金(81930041,U22A20307). （81930041,U22A20307）
