中国免疫学杂志2025，Vol.41Issue(5)：1055-1059,5.DOI:10.3969/j.issn.1000-484X.2025.05.006
特应性皮炎与强直性脊柱炎的关联:双样本孟德尔随机化研究
Association of atopic dermatitis with ankylosing spondylitis:A two-sample Mendelian randomized study
摘要
Abstract
Objective:To investigate whether there is a causal relationship between atopic dermatitis(AD)and ankylosing spondylitis(AS).Methods:Genetic data of AD and AS were extracted from genome-wide association studies(GWAS)by Mendelian randomization(MR),and inverse variance-weighted(IVW)analysis was used as main analysis,supplemented by weighted median,MR-Egger,weighted mode,etc,and verified by a series of sensitivity analyses.Results:IVW analysis of AD by AS:OR=1.015,95％CI:1.005～1.025,P=0.004.IVW analysis of AD for AS:OR=1.001,95％CI:1.000～1.002,P=0.120.Conclusion:AS has a statisti-cally small causal relationship on AD,and AD has no causal effect on AS.关键词
孟德尔随机化/特应性皮炎/强直性脊柱炎/因果推断Key words
Mendelian randomization/Atopic dermatitis/Ankylosing spondylitis/Causal inference分类
口腔医学引用本文复制引用
魏明镜,邵钲超,万昊悦,王奕恒,陈文琦..特应性皮炎与强直性脊柱炎的关联:双样本孟德尔随机化研究[J].中国免疫学杂志,2025,41(5):1055-1059,5.基金项目
南京市卫生科技发展专项基金(YKK22121). （YKK22121）
