中国全科医学2025，Vol.28Issue(20)：2562-2569,8.DOI:10.12114/j.issn.1007-9572.2024.0233
脂质代谢异常与抑郁症发展的关联及机制研究进展
Exploration of the Association and Mechanism between Abnormal Lipid Metabolism and Depressive Development
摘要
Abstract
Lipid metabolism is a key physiological process in the human body,and its disruption is closely omected with the onset and development of depression.Nevertheless,a systematic collation of these associations is currently inadequate.This article comprehensively explored the changes in lipid metabolism in patients with depression and elaborates on disorders in which disorders of lipid metabolism were co-morbidly associated with depression,such as overweight,obesity and metabolic syndrome.In addition,the article summarised five intrinsic mechanisms by which abnormalities in lipid metabolism were associated with the development of depression:overexpression of SNCA genes and abnormal accumulation of α-Syn,iron death,dysbiosis of gut microbiota,impairment of mitochondrial quality control systems,and chronic stress.Finally,this article suggested future research directions aimed at providing a new perspective and research basis for the early diagnosis and treatment of depression.关键词
抑郁症/脂类代谢/机制/α-突触核蛋白/多不饱和脂肪酸Key words
Depression/Lipid metabolism/Mechanism/Alpha-synuclein/Polyunsaturated fatty acids分类
临床医学引用本文复制引用
李欣悦,吴民民,朱路文..脂质代谢异常与抑郁症发展的关联及机制研究进展[J].中国全科医学,2025,28(20):2562-2569,8.基金项目
国家自然科学基金资助项目(82174477) （82174477）
黑龙江省重点研发项目(2022ZX06C24) （2022ZX06C24）
