中国比较医学杂志2025，Vol.35Issue(3)：109-136,28.DOI:10.3969/j.issn.1671-7856.2025.03.011
肺部"炎-癌"转化动物模型研究进展
Research progress in animal models of lung"inflammation-cancer"transformation
摘要
Abstract
Lung cancer is a serious pulmonary tumor,with exacerbation of chronic lung inflammation being a precursor to the development of lung cancer.Relevant animal models are widely used in experimental research,to gain a deeper understanding of the pathogenesis of lung cancer and to develop preventive treatment strategies.Induced lung cancer animal models are of particular importance for understanding the transition from chronic lung inflammation to lung cancer.Early intervention is crucial for the prevention and treatment of lung cancer.Here we review the recent literature regarding the inducing factors for lung cancer,including carcinogens(e.g.nicotine-derived nitrosamine ketone,benzopyrene,diethylnirtosamine atmospheric fine particulate matter(PM2.5),coal smoke,heavy metal ions,radiation,and biological infections).We also summarize animal models of lung inflammation and cancer transformation induced by these factors,discuss the mechanisms by which relevant carcinogens induce lung cancer,analyze the advantages and limitations of the animal models,and consider future development directions.This review aims is to provide a valuable reference for the future establishment of relevant models.关键词
"炎-癌"转化/肺癌/动物模型/诱发机制/优点/局限性Key words
"inflammation-cancer"transformation/lung cancer/animal models/induction mechanisms/advantages/limitations引用本文复制引用
陈亚娟,陈兰英,段文彬,黄玉清,靳旭辉..肺部"炎-癌"转化动物模型研究进展[J].中国比较医学杂志,2025,35(3):109-136,28.基金项目
国家自然科学基金(82060732) （82060732）
江西省药品监督管理局科研项目(2023JS27). （2023JS27）
