中国全科医学2025，Vol.28Issue(21)：2697-2704,8.DOI:10.12114/j.issn.1007-9572.2024.0440
内皮细胞损伤及其功能障碍在动脉粥样硬化中作用的研究进展
Research Progress on the Role of Endothelial Cell Injury and Dysfunction in Atherosclerosis
摘要
Abstract
Cardiovascular disease is a prevalent condition characterized by a high incidence rate and mortality.Atherosclerosis(AS)serves as the underlying pathological mechanism for numerous cardiovascular diseases,primarily marked by lipid accumulation and plaque formation within arterial walls,thereby impacting tissue or organ ischemia or necrosis.This comprehensive article delves into the pivotal role of endothelial cells(ECs)in atherosclerosis,elucidating their mechanisms of injury and dysfunction,as well as their interactions with macrophages and vascular smooth muscle cells(VSMCs)during this process.The findings presented herein underscore the critical involvement of ECs in AS pathogenesis,emphasizing that mitigating damage to these cells and preserving their functionality can potentially ameliorate the onset and progression of AS.Our aim is to provide novel therapeutic avenues for AS.关键词
动脉粥样硬化/内皮细胞/功能障碍/能量代谢Key words
Atherosclerosis/Endothelial cells/Dysfunction/Energy metabolism分类
医药卫生引用本文复制引用
高海钧,任佳禹,王若琳,周慧亚,曲鹏..内皮细胞损伤及其功能障碍在动脉粥样硬化中作用的研究进展[J].中国全科医学,2025,28(21):2697-2704,8.基金项目
国家自然科学基金资助项目(91739119) （91739119）
