中国比较医学杂志2025，Vol.35Issue(3)：137-146,10.DOI:10.3969/j.issn.1671-7856.2025.03.012
多囊卵巢综合征与卵泡扩张的关系及调控机制研究进展
Research progress in relationship between polycystic ovary syndrome and ovarian follicle expansion and its regulatory mechanism
摘要
Abstract
Ovarian follicle expansion is an important part of their growth and development into dominant follicles,and is regulated by a variety of molecules and signals,including follicular cavity formation,follicular fluid accumulation,and granulosa cell proliferation.Polycystic ovary syndrome(PCOS)is the most common reproductive endocrine disease in women,and patients mainly present with increased preantral follicles and polycystic ovarian lesions caused by inadequate ovarian follicle expansion.This review summarizes recent research developments concerning the physiological process of ovarian follicle expansion and the related regulatory factors and mechanisms.We also consider the possible factors restricting ovarian follicle expansion in patients with PCOS,to provide a theoretical basis for follicular dysplasia,ovulation disorders and other diseases caused by abnormal ovarian follicle expansion.关键词
卵泡扩张/卵泡腔形成/卵泡液积累/颗粒细胞增殖/多囊卵巢综合征Key words
ovarian follicle expansion/follicular cavity formation/follicular fluid accumulation/granulosa cell proliferation/polycystic ovary syndrome引用本文复制引用
张轶博,杨历,冯时光,孙洁,郝肖琼..多囊卵巢综合征与卵泡扩张的关系及调控机制研究进展[J].中国比较医学杂志,2025,35(3):137-146,10.基金项目
国家自然科学基金(32360181) （32360181）
内蒙古自治区自然科学基金(2022LHMS03012) （2022LHMS03012）
内蒙古自治区卫生健康科技计划项目(202201376) （202201376）
包头医学院2024年大学生创新创业训练计划项目(S202410130009). （S202410130009）
