中国比较医学杂志2025，Vol.35Issue(3)：147-155,9.DOI:10.3969/j.issn.1671-7856.2025.03.013
触珠蛋白在消化系统肿瘤中的研究进展
Research progress in haptoglobin in digestive system tumors
摘要
Abstract
Digestive system tumors account for more than half of all malignant tumors in terms of incidence and mortality,and thus pose a serious threat to human health.Haptoglobin(Hp)is an acute-phase glycoprotein that is elevated in both plasma and tumor tissues in various clinical conditions,including different types of cancer,such as liver,gastric,colorectal,pancreatic,and gallbladder cancer.Numerous studies have indicated that Hp plays a significant role in the prognosis of cancer patients,highlighting its potential as a prognostic marker for gastrointestinal tumors,with important clinical applications.Despite its demonstrated crucial role in the development of various tumors,however,the specific mechanisms of Hp in gastrointestinal tumors remain controversial.This review considers the differential expression and clinical significance of Hp in the five major types of gastrointestinal tumors,to explore its role in different stages of cancer progression and prognosis.This review thus aims to provide reliable and accurate serum biomarkers for the screening,early diagnosis,treatment,and prognosis monitoring of gastrointestinal tumors,with important implications for predicting the survival and prognosis of cancer patients.关键词
触珠蛋白/消化道肿瘤/糖蛋白/急性期蛋白Key words
haptoglobin/gastrointestinal tumors/glycoprotein/acute-phase protein引用本文复制引用
何超,杨春白雪,张昊,刁庆飞,贾举名,樊建春,武雪亮..触珠蛋白在消化系统肿瘤中的研究进展[J].中国比较医学杂志,2025,35(3):147-155,9.基金项目
河北省科技厅重点研发计划项目(2237784D) （2237784D）
河北省自然科学精准医学联合基金培育项目(H2022405033) （H2022405033）
河北北方学院研究生教育项目(CX202409). （CX202409）
