中国免疫学杂志2025，Vol.41Issue(5)：1197-1201,5.DOI:10.3969/j.issn.1000-484X.2025.05.029
杀伤细胞免疫球蛋白样受体基因型和单倍型与干眼病的关系
Relationship between killer cell immunoglobulin like receptor genotype and haplotype with dry eye diseas
刘云霞 1王群 1黄靖 1杨梁政 1彭洁 1任桂芳1
作者信息
摘要
Abstract
Objective:To investigate whether killer immunoglobulin-like receptor(KIR)genotypes and haplotype are associated with the dry eye disease(DED)in a Chinese Han population.Methods:Polymerase chain reaction with sequence-specific primers(PCR-SSP)method was used to genotype KIR genes in 106 DED patients and 220 healthy controls.Results:A total of 23 KIR geno-types were found in DED patients and healthy controls,including 10 newly discovered KIR genotypes.The genotype G and haplotype 4 were associated with respectively increased risk of DED(P=0.025,P=0.004);while the haplotype 2 appeared to have an inverse asso-ciation with the disease(P=0.016).The frequency of KIR genotype B/B in DED patients was also significantly higher than that in con-trol group(P=0.027).KIR haplotype A and B had distinctive centromeric(Cen)and telomeric(Tel)gene-content motifs,and the Cen-B/B was associated with increased risk of DED(P=0.037).Conclusion:There may be an association between KIR genotype and hap-loid type with DED in Han population.关键词
杀伤细胞免疫球蛋白样受体/基因型/单倍型/干眼病Key words
Killer cell immunoglobulin-like receptor/Genotype/Haplotype/Dry eye disease分类
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刘云霞,王群,黄靖,杨梁政,彭洁,任桂芳..杀伤细胞免疫球蛋白样受体基因型和单倍型与干眼病的关系[J].中国免疫学杂志,2025,41(5):1197-1201,5.
