中国免疫学杂志2025，Vol.41Issue(5)：1232-1237,6.DOI:10.3969/j.issn.1000-484X.2025.05.036
腺相关病毒在自身免疫性疾病中的研究进展
Research progress of adeno-associated virus in autoimmune diseases
摘要
Abstract
Adeno-associated virus(AAV)is a small virus that relies on other helper viruses to replicate.In recent years,with the rapid development of gene therapy,AAV has been widely used as a vector for gene therapy due to its low immunogenicity and wide host range.Many studies have shown that AAV in a variety of autoimmune diseases in animal models showed promising therapeutic effect,such as multiple sclerosis,type 1 diabetes,rheumatoid arthritis,etc,it was proved that AAV gene therapy can slow down the disease progression and reduce its severity.Transmission of autoimmune disease-related genes through AAV may become a new strategy to treat autoimmune diseases.This review will discuss the application and efficacy of AAV in autoimmune diseases based on the latest research progress.关键词
腺相关病毒/器官特异性自身免疫性疾病/全身性自身免疫性疾病Key words
Adeno-associated virus/Organ-specific autoimmune diseases/Systemic autoimmune diseases分类
医药卫生引用本文复制引用
黄薇霖,邵文威..腺相关病毒在自身免疫性疾病中的研究进展[J].中国免疫学杂志,2025,41(5):1232-1237,6.基金项目
国家自然科学基金项目(82101853) （82101853）
天津市科技计划项目(20JCZDJC00780). （20JCZDJC00780）
