中国免疫学杂志2025，Vol.41Issue(5)：1252-1256,1262,6.DOI:10.3969/j.issn.1000-484X.2025.05.039
植物病毒纳米颗粒在癌症免疫治疗中的应用
Application of plant virus nanoparticles in cancer immunotherapy
摘要
Abstract
Plant virus nanoparticles(PVNPs)have inherent immune stimulation ability,which has been widely studied as an immune adjuvant to stimulate the anti-tumor immune response.PVNPs not only have the potential to be used as vaccine adjuvants for cancer immunotherapy,but also as delivery systems for single immunotherapy or combination therapies.Among them,PVNPs have achieved great success in preclinical research of cancer immunotherapy.The new immunotherapy strategy is to use PVNPs as in situ vaccination(ISV),which can effectively inhibit tumor growth and produce a widening systemic anti-tumor immune response after in-tratumoral administration;in addition,PVNPs in combination with other tumor treatment modalities may also improve the local and systemic anti-tumor immune response.In this review,the application and prospects of plant virus nanoparticles in cancer immunotherapy are reviewed,in order to provide new ideas for cancer immunotherapy.关键词
植物病毒纳米颗粒/癌症/免疫治疗/原位疫苗/联合治疗Key words
Plant virus nanoparticles/Cancer/Immunotherapy/In situ vaccines/Combination therapy分类
生物科学引用本文复制引用
舒星富,赵钰,张博文,陈遥,马忠仁,张海霞..植物病毒纳米颗粒在癌症免疫治疗中的应用[J].中国免疫学杂志,2025,41(5):1252-1256,1262,6.基金项目
甘肃省自然科学基金项目(23JRRA717) （23JRRA717）
2023年度甘肃省教育厅高等学校创新基金项目(2023B-059) （2023B-059）
西北民族大学中央高校基本科研业务费专项资金资助项目(31920250076). （31920250076）
