中国免疫学杂志2025，Vol.41Issue(5)：1263-1270,8.DOI:10.3969/j.issn.1000-484X.2025.05.041
炎症性肠病的孟德尔随机化分析:证据、机遇和挑战
Mendelian randomization analysis of inflammatory bowel disease:Evidence,opportunities and challenges
摘要
Abstract
Inflammatory bowel disease(IBD)is a chronic inflammatory bowel disease with a complex etiology,mainly including two types:ulcerative colitis(UC)and Crohn's disease(CD),whose risk factors for its development are still incompletely understood.In recent years,Mendelian randomization(MR)has gained increasing attention in IBD research.MR mainly uses genetic variation as an instrumental variable to infer causality between exposure and outcome,effectively avoiding confounding and reverse causality in observational studies and randomised controlled trials.This review summarises currently published MR studies related to IBD,focusing on causal relationships between different risk factors and IBD development.Current findings support a causal relation-ship between IBD and selected oral diseases,skin diseases,psychiatric disorders,autoimmune diseases,bone diseases,gut diseases,gut microbiota,cytokines and nutrients,but not between IBD and lifestyle,cardiovascular diseases and neurodegenerative diseases.Despite its limitations,MR studies are of great significance in improving understanding of etiology of IBD and in identifying potential therapeutic interventions.关键词
炎症性肠病/溃疡性结肠炎/克罗恩病/孟德尔随机化/遗传变异Key words
Inflammatory bowel disease/Ulcerative colitis/Crohn's disease/Mendelian randomization/Genetic variation分类
医药卫生引用本文复制引用
郝健亨,王海军,任佳,曹玉霞,张艳林,冀来喜..炎症性肠病的孟德尔随机化分析:证据、机遇和挑战[J].中国免疫学杂志,2025,41(5):1263-1270,8.基金项目
国家自然科学基金面上项目(82074549). （82074549）
