中国免疫学杂志2025，Vol.41Issue(5)：1277-1280,后插1,5.DOI:10.3969/j.issn.1000-484X.2025.05.043
铜死亡在结缔组织病中的研究进展
Research progress on copper death in connective tissue diseases
摘要
Abstract
Connective tissue disease(CTD)is based on chronic inflammation of blood vessels and connective tissue,often involving multiple systems.The basic pathological changes are necrotizing vasculitis,myxedema,fibrin like deformation,etc.It belongs to systemic autoimmune disease.Due to the complex pathogenesis and heterogeneity of CTD,developing personalized manage-ment strategies remains extremely challenging.Therefore,exploring the new mechanisms and treatment targets of CTD is the focus of CTD research work.In recent years,with the continuous deepening of research on CTD,it has been discovered that there is a new form of cell death in the pathological process of CTD,namely copper death.Similar to ferroptosis,copper induces cytotoxicity mediated cell death through increased mitochondrial dependent energy metabolism and accumulation of reactive oxygen species.This article mainly attempts to explore the relationship between copper death and the pathological mechanism of confirmed CTD,as well as its impact on various immune cells,as well as the opportunities and challenges faced by therapeutic targets and clinical drugs.关键词
结缔组织病/铜死亡/TCA循环/氧化应激/炎症Key words
Connective tissue disease/Copper death/TCA cycle/Oxidative stress/Inflammation分类
医药卫生引用本文复制引用
钱爱,朱雅文,程园园,黄传兵..铜死亡在结缔组织病中的研究进展[J].中国免疫学杂志,2025,41(5):1277-1280,后插1,5.基金项目
安徽省高校协同创新项目(GXXT-2021-085) （GXXT-2021-085）
安徽省红十字基金会中医药传承创新发展研究项目(2021ZYZD03) （2021ZYZD03）
安徽省名中医工作室建设项目(中发展[2022]5号) （中发展[2022]5号）
安徽省中医优势专科(皖中医药服务秘[2022]34号) （皖中医药服务秘[2022]34号）
安徽省卫生健康科研项目重点项目(AHWJ2022a005). （AHWJ2022a005）
