中国药理学通报2025，Vol.41Issue(5)：805-810,6.DOI:10.12360/CPB202410035
慢性阻塞性肺疾病的气道上皮细胞衰老机制研究进展
Research progress of airway epithelial cell senescence mechanism in chronic obstructive pulmonary disease
摘要
Abstract
As the first defense of respiratory system,airway epi-thelial cells(AECs)play an important role in separating the re-spiratory internal and external environment.They are essential for the natural immune function.Small airway lesions are an im-portant early pathology of chronic obstructive pulmonary disease(COPD),when AECs are exposed to harmful particles or gases for a long time,the epithelial barrier is damaged,and the signa-ling pathways which involved in differentiation,repair,and in-flammatory are disordered,resulting in epithelial cell cycle stag-nation and accelerated aging.A number of studies have sugges-ted that AECs of COPD patients express high levels of aging markers,suggesting that senescence of AECs is closely related to COPD.This review discusses the potential mechanisms of AECs senescence in COPD,the impact of AECs senescence on the de-velopment and severity of the disease,and highlights potential targets for modulating cellular senescence in airway epithelium as a therapeutic approach in COPD.关键词
慢性阻塞性肺疾病/气道上皮细胞/衰老/DNA损伤/表观遗传修饰/慢性炎症/氧化应激/线粒体自噬/衰老细胞治疗Key words
chronic obstructive pulmonary disease/airway epi-thelial cells/senescence/DNA damage/epigenetic modifica-tion/chronic inflammation/oxidative stress/mitochondrial auto-phagy/senotherapy分类
医药卫生引用本文复制引用
栗兆靓,王略力,仪倩,马若秋,郭蓉,徐长莉,杜晓华,杨为民..慢性阻塞性肺疾病的气道上皮细胞衰老机制研究进展[J].中国药理学通报,2025,41(5):805-810,6.基金项目
国家自然科学基金项目(No 81870037,82160013,82160007) （No 81870037,82160013,82160007）
云南省科技厅重点项目(No 202105AF150015,202102AA310030,202302AA310026) （No 202105AF150015,202102AA310030,202302AA310026）
