中国药理学通报2025，Vol.41Issue(5)：811-815,5.DOI:10.12360/CPB202409027
脑类淋巴系统AQP4极化分布的调控机制研究进展
Research progress on regulatory mechanism of AQP4 polarization distribution in glymphatic system
摘要
Abstract
The glymphatic system(GS)is a unique toxic sub-stance clearance system in brain,which is very important for maintaining the microenvironment stability of the central nervous system.The polarization distribution of aquaporin 4(AQP4)lo-cated in the terminal foot of astrocytes affects the function of GS and participates in the pathological progress of many neurodegen-erative diseases,but the detailed regulation mechanism of AQP4 polarization distribution has not been systematically summarized.Therefore,this paper systematically combs the mechanism of reg-ulating the polarization distribution of AQP4 from the perspective of the composition integrity of dystrophin-glycoprotein complex(DGC)and basement membrane foot complex,and summarizes the potential drug and non-drug therapies for targeted regulation of AQP4 polarization distribution at present,aiming at providing new target reference and theoretical basis for targeted regulation of AQP4 polarization to prevent and treat neurodegenerative dis-eases.关键词
类淋巴系统/星形胶质细胞/水通道蛋白4/极化分布/肌营养不良蛋白-糖蛋白复合物/基底膜Key words
glymphatic system/astrocytes/AQP4/polarization distribution/dystrophin-glycoprotein complex/basement mem-brane分类
医药卫生引用本文复制引用
林雪玲,李英,任家乐,张艳军,庄朋伟,尹清晟..脑类淋巴系统AQP4极化分布的调控机制研究进展[J].中国药理学通报,2025,41(5):811-815,5.基金项目
国家自然科学基金资助项目(No 82174112) （No 82174112）
现代中医药海河实验室科技项目(No 22HHZYSS00015) （No 22HHZYSS00015）
