中国药理学通报2025，Vol.41Issue(5)：816-820,5.DOI:10.12360/CPB202409023
坏死性凋亡在慢性肾脏病中的作用机制进展
Research progress on role of necroptosis in chronic kidney disease
摘要
Abstract
Chronic kidney disease(CKD)is a chronic disease characterized by renal structural damage and dysfunction.At present,there is still a lack of effective therapeutic drugs and prevention and treatment methods for CKD in clinical practice.More and more studies have shown that necroptosis,as a new type of programmed cell death,plays a vital role in the onset and progression of CKD.Targeting key molecules in the necroptosis pathway,such as RIPK1,RIPK3 and MLKL,the development of small molecule inhibitors has become an emerging strategy for the treatment of CKD,and has shown significant potential to pro-tect the kidneys and alleviate renal fibrosis in a variety of in vitro and in vivo models.Therefore,this article summarizes the re-search progress of the mechanism of necroptosis in recent years,and focuses on the potential role of necroptosis in the pathogene-sis of CKD and the therapeutic potential of targeting this path-way,providing a new perspective and research direction for the prevention and treatment of CKD in the future.关键词
坏死性凋亡/慢性肾脏病/肾纤维化/RIPK1/小分子抑制剂/MLKLKey words
necroptosis/chronic kidney disease/renal fibrosis/RIPK1/small molecule inhibitors/MLKL分类
医药卫生引用本文复制引用
邱萍,黄朔,骆启晗,马青,陈傅喆,单子怡,刘一鸣,李昌煜..坏死性凋亡在慢性肾脏病中的作用机制进展[J].中国药理学通报,2025,41(5):816-820,5.基金项目
国家自然科学基金资助项目(No 82074304,82003830) （No 82074304,82003830）
浙江中医药大学校级科研基金(No 2021JKZKTS016B) （No 2021JKZKTS016B）
"尖兵""领雁"研发攻关计划项目(No 2023C03004) （No 2023C03004）
