中国现代医学杂志2025，Vol.35Issue(9)：27-32,6.DOI:10.3969/j.issn.1005-8982.2025.09.005
冻干重组人脑钠肽联合比伐卢定对急性冠脉综合征患者PCI术后心功能、炎症水平的影响
Effects of freeze-dried recombinant human brain natriuretic peptide combined with bivalirudin on cardiac function and inflammation in patients with acute coronary syndrome after PCI
摘要
Abstract
Objective To investigate the effects of freeze-dried recombinant human brain natriuretic peptide(rhBNP)combined with bivalirudin on cardiac function and inflammation in acute coronary syndrome(ACS)patients after percutaneous coronary intervention(PCI).Methods From May 2020 to March 2022,112 post-PCI ACS patients at our hospital were randomly divided into observation(n=56,rhBNP+bivalirudin)and control(n=56,rhBNP+heparin sodium)groups.Cardiac function(LVEF,LVEDD,FS,IVRT),inflammatory markers(MMP-9,NO,ET-1,hs-CRP),adverse events,and event-free survival were compared.Results The observation group showed greater LVEF improvement(P<0.05)and greater LVEDD reduction(P<0.05)versus controls.No intergroup differences existed in FS,IVRT,or inflammatory marker changes(all P>0.05).The observation group had lower adverse event rates(P<0.05)and longer 1-year cardiovascular event-free survival(P<0.05).Conclusion rhBNP-bivalirudin combination improves cardiac function with better safety than heparin sodium in post-PCI ACS patients.关键词
急性冠脉综合征/经皮冠脉介入术/重组人脑钠肽/比伐卢定/心功能/炎症水平Key words
acute coronary syndrome/percutaneous coronary intervention/recombinant human brain natriuretic peptide/bivalirudin/heart function/inflammation level分类
医药卫生引用本文复制引用
张淑翼,李娜惠,郝晓东..冻干重组人脑钠肽联合比伐卢定对急性冠脉综合征患者PCI术后心功能、炎症水平的影响[J].中国现代医学杂志,2025,35(9):27-32,6.基金项目
天津市医学重点学科(专科)建设项目(No:TJYXZDXK-013A) （专科）
