中国药理学通报2025，Vol.41Issue(5)：820-824,5.DOI:10.12360/CPB202409099
线粒体分裂/融合动态变化在变应性疾病中的研究进展
Advances in research on mitochondrial fission and fusion dynamics in allergic diseases
摘要
Abstract
Mitochondrial dynamics refer to two modes of move-ment:mitochondrial fission and mitochondrial fusion.Stimula-tion from internal and external sources promotes the occurrence of mitochondrial dynamic changes,supporting cellular functional changes to adapt to physiological and pathological changes.This article systematically reviews relevant literature,providing an o-verview of the dynamic changes in mitochondrial fission/fusion from both physiological and pathological perspectives.It summa-rizes the essence of these changes by highlighting functional al-terations,including ion homeostasis,redox balance,energy me-tabolism,and programmed death signaling,and reveals the un-derlying mechanisms of action.Additionally,by focusing on key cellular components in allergic diseases,it discusses the impact of functional alterations in mitochondrial dynamic division/fusion on allergic diseases.Progressively examining the concept,func-tional alterations,and impact on allergic diseases,this study es-tablishes a connection between mitochondrial fission/fusion dy-namics and key cellular components of allergic diseases.It con-structs a networked map that outlines how these dynamics modu-late the progression of allergic diseases through diverse cellular components,aiming to guide mechanistic studies and systematic treatments for these diseases.关键词
线粒体动力学/线粒体/超敏反应/变应性疾病/肥大细胞/2型天然淋巴细胞Key words
mitochondrial dynamics/mitochondria/hypersensi-tivity/allergic diseases/mast cells/type 2 innate lymphocytes引用本文复制引用
何开元,周龙云,陈旭青,吴拥军..线粒体分裂/融合动态变化在变应性疾病中的研究进展[J].中国药理学通报,2025,41(5):820-824,5.基金项目
国家自然科学基金面上项目(No 82374527) （No 82374527）
国家自然科学青年科学基金项目(No 82205148) （No 82205148）
