中国药理学通报2025，Vol.41Issue(5)：825-829,5.DOI:10.12360/CPB202402036
脑源性神经营养因子DNA甲基化与抑郁
Advances in DNA methylation of brain-derived neurotrophic factor and depression
摘要
Abstract
Depression is a heterogeneous mental disorder in which the interaction between genetic susceptibility and environ-mental factors plays a key role in its pathogenesis.Although the specific mechanisms of the disease still need to be thoroughly studied and elucidated,there is now a broad consensus that epi-genetic markers have a central influence on its mechanism of ac-tion.DNA methylation of brain-derived neurotrophic factor(BD-NF)is not only regarded as a promising epigenetic biomarker of pathology,but may also help predict the efficacy of antidepres-sants.In this paper we reviewed the gene structure of BDNF and its DNA methylation regulation mechanism,and also analyzed the changes of DNA methylation of this factor in depression pa-tients and animal models,aiming to provide new ideas and theo-retical support for clinical research.关键词
脑源性神经营养因子/DNA甲基化/基因结构/抑郁/启动子/外显子Key words
brain-derived neurotrophic factor/DNA methyla-tion/genetic structure/depression/promoter/exon分类
医药卫生引用本文复制引用
廖紫云,王孟雨,乔靖怡,张润,刘培东,陈新旺..脑源性神经营养因子DNA甲基化与抑郁[J].中国药理学通报,2025,41(5):825-829,5.基金项目
国家自然基金青年基金项目(No 82305417) （No 82305417）
河南省科技攻关项目(No 232102311217) （No 232102311217）
河南省中医药科学研究专项课题(No 2022ZY2061) （No 2022ZY2061）
