中国现代医学杂志2025，Vol.35Issue(9)：63-69,7.DOI:10.3969/j.issn.1005-8982.2025.09.010
线粒体ALDH2在心力衰竭中的作用研究进展
Research advances on the role of mitochondrial ALDH2 in heart failure
摘要
Abstract
The incidence of chronic heart failure(CHF)continues to escalate,imposing a tremendous burden on public health and quality of life,and has now become a leading cause of mortality globally.Mitochondrial aldehyde dehydrogenase 2(ALDH2),a critical enzyme in aldehyde metabolism located in the mitochondrial matrix,exerts cardioprotective effects in myocardial cells by scavenging harmful aldehydes and modulating associated proteins and signaling factors.Extensive literature in recent years has substantiated its pivotal role in the initiation and progression of chronic heart failure.This article primarily provides a review of the research on the mechanisms by which mitochondrial ALDH2 operates in heart failure.关键词
心力衰竭/线粒体乙醛脱氢酶2/作用机制/研究进展Key words
heart failure/mitochondrial aldehyde dehydrogenase 2/mechanism of action/research progress分类
医药卫生引用本文复制引用
李晨,隋艳波..线粒体ALDH2在心力衰竭中的作用研究进展[J].中国现代医学杂志,2025,35(9):63-69,7.基金项目
国家自然科学基金青年基金项目(No:81904107) （No:81904107）
黑龙江省自然科学基金联合引导项目(No:LH2022H071) （No:LH2022H071）
