中国现代医学杂志2025，Vol.35Issue(9)：70-77,8.DOI:10.3969/j.issn.1005-8982.2025.09.011
基于"阴阳学说"理论探讨线粒体自噬介导的PINK1/Parkin信号通路在动脉粥样硬化中的调控机制
Role and mechanism of mitochondrial autophagy mediated by the PINK1/Parkin signaling pathway in atherosclerosis based on the theory of Yin-Yang
摘要
Abstract
Atherosclerosis(AS)is a common vascular disease characterized by lipid accumulation and plaque formation in arteries,with high incidence and mortality rates that severely affect global human health.Mitochondria,serving as the energy center and regulator of cells,participate in various metabolic processes within cells and exert significant influence on the occurrence and development of atherosclerosis.Mitochondrial autophagy,which describes the selective autophagy process of mitochondria,is a key mechanism for maintaining cellular mitochondrial health and plays important roles in both physiological and pathological conditions.Among these,the PINK1/Parkin-mediated pathway is the most characteristic signaling pathway and plays a crucial role in AS.Its regulation is similar to the characteristics of Yin and Yang balance,including opposition,mutual restriction,mutual dependence,and the properties of"Yang"which is driving,warming,and defending,and"Yin"which is static,cold,and inward,according to traditional Chinese medicine theory.This article,based on the theory of Yin and Yang,explores the mechanism of action of the mitochondrial autophagy PINK1/Parkin signaling pathway in AS and provides new ideas for the prevention and treatment of AS through traditional Chinese medicine and compound interventions.关键词
动脉粥样硬化/阴阳理论/线粒体自噬/PINK1/Parkin信号通路/中医药Key words
atherosclerosis/Yin-Yang theory/mitophagy/PINK1/Parkin signaling pathway/traditional Chinese medicine分类
临床医学引用本文复制引用
柳岳,陈杏,张书萌,刘映志,陆玉雯,朱赟,陈伶利,李杰..基于"阴阳学说"理论探讨线粒体自噬介导的PINK1/Parkin信号通路在动脉粥样硬化中的调控机制[J].中国现代医学杂志,2025,35(9):70-77,8.基金项目
国家自然科学基金(No:81874375) （No:81874375）
湖南省自然科学基金面上项目(No:2023JJ30452) （No:2023JJ30452）
湖南省中医药科研重点课题(No:C2023002) （No:C2023002）
湖南中医药大学研究生创新课题(No:2024CX150,2024CX151,2024CX152) （No:2024CX150,2024CX151,2024CX152）
湖南省普通高等学校科技创新团队支持项目(No:2023) （No:2023）
