中国药业2025，Vol.34Issue(9)：75-79,5.DOI:10.3969/j.issn.1006-4931.2025.09.016
微波消解-电感耦合等离子体质谱法同时测定蒙脱石散中36种无机元素杂质含量
Determination of 36 Inorganic Elemental Impurities in Montmorillonite Powder by Microwave Digestion-ICP-MS
摘要
Abstract
Objective To establish an inductively coupled plasma-mass spectrometry(ICP-MS)method for the simultaneously determination of 36 inorganic element impurities in Montmorillonite Powder.Methods Microwave digestion method was used to process the sample,the testing mode was kinetic energy discrimination(KED),the plasma output power was 1 550 W,the sampling depth was 8 mm,and the maximum current carrying capacity was 1.045 L/min,the flow rate of cooling air was 14 L/min,the flow rate of auxiliary air was 0.9 L/min,the speed of peristaltic pump was 40 r/min,the injection system was an acid resistant system,with manual injection and repeated measurements three times.Results The 36 inorganic element impurities had a good linear relationship(r>0.995,n=6).The RSD of the repeatability test was in the range of 3.13%-15.06%(n=6),and the RSD of the intra-day precision test was in the range of 1.85%-11.56%.The average recoveries of 36 inorganic element impurities were in the range of 77.17%-102.85%,with RSDs of 1.67%-15.16%(n=9).The impurity content of 36 inorganic element impurities in five batches of samples was lower than the limit value and control threshold.Conclusion This method has high sensitivity and good accuracy,which can be used for the content determination of 36 inorganic element impurities in Montmorillonite Powder.关键词
蒙脱石散/电感耦合等离子体质谱法/微波消解法/无机元素杂质/质量控制Key words
Montmorillonite Powder/ICP-MS/microwave digestion method/inorganic element impurities/quality control分类
药学引用本文复制引用
熊欢,陈萱,朱琼..微波消解-电感耦合等离子体质谱法同时测定蒙脱石散中36种无机元素杂质含量[J].中国药业,2025,34(9):75-79,5.基金项目
江苏省市场监督管理局科技计划项目[KJ2023074]. （）
