中国现代医学杂志2025，Vol.35Issue(9)：78-84,7.DOI:10.3969/j.issn.1005-8982.2025.09.012
2型糖尿病患者血清LGMN水平与颈动脉粥样硬化的相关性研究
Correlation between serum legumain and carotid atherosclerosis in patients with type 2 diabetes mellitus
摘要
Abstract
Objective To investigate the relationship between serum legumain(LGMN)levels and carotid atherosclerosis(CAS)in patients with type 2 diabetes mellitus(T2DM).Methods We enrolled 111 T2DM patients from Baoding No.1 Central Hospital between May 2023 and May 2024,classifying them into T2DM group(n=55)and T2DM+CAS group(n=56)based on carotid intima-media thickness(CIMT),with 55 healthy controls(NC group).Clinical data were collected,serum LGMN was measured by ELISA,and correlations were analyzed using Spearman's method.Multivariate logistic regression identified risk factors for T2DM+CAS,and receiver operating characteristic(ROC)curves evaluated LGMN's diagnostic value.Results Significant differences existed among groups for BMI,SBP,FBG,HbA1c,FINS,HOMA-IR,and LGMN(all P<0.05).T2DM+CAS group showed highest HbA1c and LGMN levels(P<0.05 vs NC).LGMN positively correlated with BMI(rₛ=0.303),SBP(rₛ=0.400),FPG(rₛ=0.639),HbA1c(rₛ=0.699),FINS(rₛ=0.340),HOMA-IR(rₛ=0.493),and CIMT(rₛ=0.580)(all P=0.000).Elevated HbA1c[(OR)=1.944(95%CI:1.311,2.883)]and LGMN[(OR)=1.495(95%CI:1.273,1.756)]were independent risk factors for T2DM+CAS(P<0.05).LGMN's AUC for diagnosing T2DM+CAS was 0.870(95%CI:0.819,0.924),with 87.5%(95%CI:0.788,0.962)sensitivity and 73.6%(95%CI:0.654,0.819)specificity.Conclusions Serum LGMN elevation is significantly associated with CAS in T2DM patients,potentially serving as a novel biomarker for T2DM complicated by CAS.关键词
2型糖尿病/颈动脉粥样硬化/天冬酰胺内肽酶/胰岛素抵抗Key words
type 2 diabetes mellitus/carotid atherosclerosis/legumain/insulin resistance分类
临床医学引用本文复制引用
董越华,李苗,杨聪聪,王翯,张云良..2型糖尿病患者血清LGMN水平与颈动脉粥样硬化的相关性研究[J].中国现代医学杂志,2025,35(9):78-84,7.基金项目
河北省医学适用技术跟踪项目(No:GZ2023046) （No:GZ2023046）
