中国现代医学杂志2025，Vol.35Issue(9)：85-91,7.DOI:10.3969/j.issn.1005-8982.2025.09.013
青少年双相障碍抑郁发作患者神经代谢的性别差异研究
Study on gender differences in neurometabolism of adolescents with bipolar disorder in depressive episodes
摘要
Abstract
Objective To investigate gender differences in neurometabolite levels within the ventromedial prefrontal cortex(vmPFC)of adolescent patients with bipolar disorder during depressive episodes.Methods We recruited 45 treatment-naïve adolescents(20 males,25 females)meeting DSM-5 criteria for bipolar depressive episodes within the past month.Depression severity was assessed using the Hamilton Depression Rating Scale-24(HAMD-24).Proton magnetic resonance spectroscopy(¹H-MRS)quantified vmPFC concentrations of myo-inositol(mI),choline(Cho),N-acetylaspartate(NAA),and creatine(Cr)Results No significant demographic or clinical differences existed between genders(all P>0.05).Female patients showed significantly higher NAA/Cr ratios than males(P<0.05).Male patients demonstrated negative correlations between vmPFC mI/Cr and illness duration(rₛ=-0.467,P<0.05),while both genders showed positive Cho/Cr-HAMD score correlations(males:r=0.553;females:r=0.621;both P<0.05).Conclusion Adolescent female bipolar depression patients exhibit elevated NAA levels in vmPFC regions compared to males,suggesting sex-specific neurometabolic profiles.关键词
双相障碍/抑郁发作/青少年/性别/神经代谢/氢质子磁共振波谱Key words
adolescents/bipolar disorder/depressive episode/gender/neurometabolism/proton magnetic resonance spectroscopy分类
临床医学引用本文复制引用
王丞基,迪丽娜孜·卡日,阿亚阔孜·杰克山别克,李迎帅,张龙渊,阿地拉·阿吉,曲源,邹韶红..青少年双相障碍抑郁发作患者神经代谢的性别差异研究[J].中国现代医学杂志,2025,35(9):85-91,7.基金项目
新疆维吾尔自治区自然科学基金(No:2022D01C606) （No:2022D01C606）
天山创新团队计划(No:2022D14011) （No:2022D14011）
