中国药业2025，Vol.34Issue(9)：85-89,5.DOI:10.3969/j.issn.1006-4931.2025.09.018
依托咪酯靶控输注复合帕瑞昔布钠超前镇痛麻醉对膝关节置换术后患者氧化应激及认知功能的影响
Effect of Target-Controlled Infusion of Etomidate Combined with Parecoxib Sodium for Preemptive Analgesia on Oxidative Stress and Cognitive Function After Knee Arthroplasty
摘要
Abstract
Objective To investigate the effect of target-controlled infusion of etomidate combined with parecoxib sodium for preemptive analgesia on oxidative stress and cognitive function after knee arthroplasty.Methods A total of 93 patients who underwent knee arthroplasty in the Second Affiliated Hospital of Hunan University of Traditional Chinese Medicine from March 2021 to March 2023 were selected and randomly divided into the control group(45 cases)and the study group(48 cases)by the random number table method.The patients in the two groups received preemptive analgesia with parecoxib sodium,on this basis,the patients in the study group received target-controlled infusion of etomidate.Results Compared with those before surgery,the Visual Analog Scale(VAS)scores and Mini-Mental State Examination(MMSE)scores at 12,24,and 48 h after surgery in the two groups significantly decreased(P<0.05),while the knee joint function score(HSS)scores at 12,24,and 48 h after surgery significantly increased(P<0.05),and those in the study group were significantly better than those in the control group(P<0.05);the heart rate and mean arterial pressure in the two groups at 1 and 2 h after surgery significantly increased(P<0.05),but those in the study group were significantly lower than those in the control group(P<0.05);the levels of interleukin-6,C-reactive protein,tumor necrosis factor-α,norepinephrine,and cortisol at 12,24,and 48 h after surgery in the two groups significantly increased(P<0.05),but those in the study group were significantly lower than those in the control group(P<0.05).The incidence of adverse reactions was comparable between the study group and the control group(14.58%vs.13.33%,P>0.05).Conclusion Target-controlled infusion of etomidate combined with parecoxib sodium for preemptive analgesia has little effect on hemodynamics,stress response,and inflammatory factor levels in patients undergoing knee arthroplasty,which can reduce the postoperative pain degree,improve cognitive function and knee joint function,and has ideal anesthesia effect.关键词
膝关节置换术/依托咪酯靶控输注/帕瑞昔布钠超前镇痛/氧化应激/认知功能Key words
knee arthroplasty/target-controlled infusion of etomidate/parecoxib sodium for preemptive analgesia/oxidative stress/cognitive function分类
医药卫生引用本文复制引用
黄珍,王勇,黎浪,李宇峰..依托咪酯靶控输注复合帕瑞昔布钠超前镇痛麻醉对膝关节置换术后患者氧化应激及认知功能的影响[J].中国药业,2025,34(9):85-89,5.基金项目
湖南省卫生健康委员会科研立项课题[20201290]. （）
