中国药业2025，Vol.34Issue(9)：97-100,4.DOI:10.3969/j.issn.1006-4931.2025.09.021
健脾利湿解毒方联合抗人乳头瘤病毒蛋白辅料治疗宫颈锥切术后持续感染人乳头瘤病毒临床观察
Clinical Observation of Jianpi Lishi Jiedu Formula Combined with Anti-HPV Protein Excipients in the Treatment of Patients with Persistent HPV Infection After Cervical Conectomy
摘要
Abstract
Objective To investigate the clinical efficacy of the Jianpi Lishi Jiedu Formula combined with anti-human papillomavirus(HPV)protein excipients in the treatment of patients with persistent HPV infection after cervical conectomy.Methods A total of 96 patients with persistent HPV infection after cervical conectomy admitted to the hospital from June 2022 to June 2023 were selected and randomly divided into the control group and the observation group by the random number table method,with 48 cases in each group.The patients in the two groups were treated with anti-HPV protein excipients,while the patients in the observation group were given an oral administration of Jianpi Lishi Jiedu Formula.Both groups were treated for three consecutive courses of treatment with 30 d as a course of treatment(drug withdrawal during menstruation).Results The total effective rate in the observation group was 91.67%,which was significantly higher than 72.92%in the control group(P<0.05).After treatment,the traditional Chinese medicine(TCM)syndrome(vaginal discharge,menostaxis,lumbosacral pain,tongue redness and yellow coating)scores,inflammatory factors(serum amyloid A,granulocyte colony-stimulating factor,interleukin-33)levels,and immune function index[helper T cell 2(Th2)]level in the two groups significantly decreased(P<0.05),and those in the observation group were significantly lower than those in the control group(P<0.05);the levels of helper T cell 1(Th1)level and Th1/Th2 in the two groups significantly increased(P<0.05),and those in the observation group were significantly higher than those in the control group(P<0.05).During the treatment period,the incidence of adverse reactions was comparable between the observation group and the control group(12.50%vs.8.33%,P>0.05).Conclusion Jianpi Lishi Jiedu Formula combined with anti-HPV protein excipients has good efficacy and safety in the treatment of patients with persistent HPV infection after cervical conectomy,which can alleviate patients'TCM syndromes,reduce inflammatory factor levels,and improve immune function.关键词
抗人乳头瘤病毒蛋白辅料/健脾利湿解毒方/人乳头瘤病毒/宫颈锥切术后/中医证候/炎性因子/免疫功能/临床疗效Key words
anti-human papillomavirus protein excipient/Jianpi Lishi Jiedu Formula/human papillomavirus/cervical conectomy/traditional Chinese medicine syndrome/inflammatory factors/immune function/clinical efficacy分类
医药卫生引用本文复制引用
倪雅丽,颛佳,赵云彦,孙佳,陈瑞雪,邵迎华,杨秀梅..健脾利湿解毒方联合抗人乳头瘤病毒蛋白辅料治疗宫颈锥切术后持续感染人乳头瘤病毒临床观察[J].中国药业,2025,34(9):97-100,4.基金项目
河北省中医药管理局科研计划项目[2023456]. （）
