中国药业2025，Vol.34Issue(9)：101-105,5.DOI:10.3969/j.issn.1006-4931.2025.09.022
射麻口服液联合吸入用布地奈德混悬液对肺炎支原体肺炎患儿免疫功能与外周血Toll样受体2信号通路表达水平的影响
Effect of Shema Oral Liquid Combined with Suspension for Inhalation on Immune Function and Expression of TLR2 Signaling Pathway in Peripheral Blood of Children with Mycoplasma Pneumoniae Pneumonia
摘要
Abstract
Objective To investigate the effect of Shema Oral Liquid combined with Suspension for Inhalation on immune function and Toll-like receptor 2(TLR2)signaling pathway in the peripheral blood of children with Mycoplasma pneumoniae pneumonia.Methods A total of 104 children with Mycoplasma pneumoniae pneumonia admitted to the Yuexi Hospital of Traditional Chinese Medicine from January 2022 to December 2023 were selected and divided into the observation group and the control group by the random number table method,with 52 cases in each group.The children in the two groups were treated with conventional therapy and Budesonide Suspension for Inhalation,while the patients in the observation group were treated with Shema Oral Liquid.Both groups were treated continuously for 7 d.Results After treatment,the traditional Chinese medicine(TCM)syndrome score,C-reactive protein,procalcitonin,interleukin-6,the expression levels of TLR2,myeloid differentiation factor 88(MyD88),and nuclear transcription factor-κB(NF-κB),and the expression levels of TLR2,MyD88,NF-κB mRNA in the two groups significantly decreased(P<0.05),and those in the observation group were significantly lower than those in the control group(P<0.05).The expression levels of immunoglobulin A,immunoglobulin G,and immunoglobulin M in the two groups significantly increased(P<0.05),and those in the observation group were significantly higher than those in the control group(P<0.05).The total clinical effective rate in the observation group was 96.15%,which was significantly higher than 80.77%in the control group(P<0.05).The incidence of adverse reactions was comparable between the observation group and the control group(13.46%vs.9.62%,P>0.05).Conclusion Shema Oral Liquid combined with Suspension for Inhalation has good clinical efficacy and safety in the treatment of Mycoplasma pneumoniae pneumonia,which can improve the clinical symptoms of children,and enhance immune function.Its mechanism may be reducing the occurrence of downstream inflammatory reactions by down-regulating the expression of the TLR2 signaling pathway.关键词
射麻口服液/吸入用布地奈德混悬液/肺炎支原体肺炎/免疫功能/Toll样受体 2 信号通路Key words
Shema Oral Liquid/Budesonide Suspension for Inhalation/Mycoplasma pneumoniae pneumonia/immune function/TLR2 signaling pathway分类
医药卫生引用本文复制引用
胡霏,储振宇,唐赞..射麻口服液联合吸入用布地奈德混悬液对肺炎支原体肺炎患儿免疫功能与外周血Toll样受体2信号通路表达水平的影响[J].中国药业,2025,34(9):101-105,5.基金项目
安徽省卫生计生委科研计划项目[2022AM046]. （）
