中国卒中杂志2025，Vol.20Issue(4)：479-485,7.DOI:10.3969/j.issn.1673-5765.2025.04.012
基于cGAS-STING通路和突触融合蛋白17介导的自噬在脑缺血再灌注损伤中的作用研究进展
Research Progress on the Role of cGAS-STING Pathway and Syntaxin 17 Mediated Autophagy in Cerebral Ischemia-Reperfusion Injury
摘要
Abstract
After acute ischemic stroke,cerebral ischemia-reperfusion injury(CIRI)can further damage the neurological function of patients and affect their prognosis.Autophagy is a"double-edged sword"in the pathological process of CIRI.The varying stages and degrees of activation of CIRI can have opposing effects,either protecting or damaging brain tissue.The cyclic guanosine monophosphate-adenosine monophosphate synthase(cGAS)-stimulator of interferon gene(STING)pathway is an important pattern recognition and effector pathway in the innate immune response.Syntaxin 17(STX17)is a member of the soluble N-ethylmaleimide-sensitive factor attachment protein receptor subfamily.Both play significant regulatory roles in autophagy and mitophagy during the CIRI process.This article reviews the mechanisms and interrelationships between the cGAS-STING pathway and STX17 in regulating autophagy during CIRI,aiming to provide new ideas and evidence for the intervention of CIRI.关键词
环鸟苷酸-腺苷酸合酶-干扰素基因刺激因子通路/突触融合蛋白17/自噬/脑缺血再灌注损伤Key words
Cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon gene pathway/Syntaxin 17/Autophagy/Cerebral ischemia-reperfusion injury分类
临床医学引用本文复制引用
杨航,高安邦,倪莹,马跃,高名同..基于cGAS-STING通路和突触融合蛋白17介导的自噬在脑缺血再灌注损伤中的作用研究进展[J].中国卒中杂志,2025,20(4):479-485,7.基金项目
潍坊市卫生健康委员会科研项目(WFWJWK-2024-180) （WFWJWK-2024-180）
