中国卒中杂志2025，Vol.20Issue(4)：486-492,7.DOI:10.3969/j.issn.1673-5765.2025.04.013
基于脑-肠轴探讨针灸治疗缺血性卒中机制的基础研究进展
Research Progress on the Mechanism of Acupuncture in Treating Ischemic Stroke Based on the Gut-Brain Axis
摘要
Abstract
Acupuncture,as an important part of traditional Chinese medicine,has received widespread attention in recent years for its mechanisms in the treatment of ischemic stroke.This paper summarizes and analyzes the basic research on acupuncture treating ischemic stroke through modulation of the gut-brain axis.It is found that it may involve the following mechanisms.Firstly,it modulates the gut microbiota composition by inhibiting the proliferation of pathogenic bacteria and promoting the colonization of beneficial bacteria.It also enhances the expression of intestinal epithelial tight junction protein to maintain gut barrier function and reduce enterotoxin entry into the bloodstream.Secondly,it inhibits the overactivation of the hypothalamic-pituitary-adrenal axis through neuroendocrine regulation,reduces the release of pro-inflammatory cytokine,and activates the anti-inflammatory pathways mediated by the vagus nerve.Thirdly,it regulates the dynamic balance of gut microbiota metabolic products such as short-chain fatty acids and trimethylamine N-oxide,ameliorating the systemic inflammatory microenvironments.Fourthly,it reshapes the proportion of immune cell subpopulations,inhibits excessive inflammation reactions,and facilitates neural repair.By synthesizing recent research advancements,this paper reviews potential therapeutic targets and pathways through which acupuncture modulates ischemic stroke via the gut-brain axis,aiming to provide a basis for subsequent basic research and clinical application of acupuncture.关键词
针灸/缺血性卒中/脑-肠轴/肠道菌群/肠道屏障/免疫调节Key words
Acupuncture/Ischemic stroke/Gut-brain axis/Gut microbiota/Gut barrier/Immune regulation分类
临床医学引用本文复制引用
赵乾坤,李宪东,徐天策,陈会生..基于脑-肠轴探讨针灸治疗缺血性卒中机制的基础研究进展[J].中国卒中杂志,2025,20(4):486-492,7.基金项目
国家自然科学基金面上项目(82071477) （82071477）
