中国中医药信息杂志2025，Vol.32Issue(4)：51-57,7.DOI:10.19879/j.cnki.1005-5304.202411138
基于隐结构模型和聚类分析的结直肠癌常见中医证候研究
Study on Common TCM Syndromes of Colorectal Cancer Based on Latent Structure Model Combined with Clustering Analysis
摘要
Abstract
Objective To explore the distribution characteristics of common TCM syndromes in colorectal cancer;To provide a basis for standardized research on syndrome of colorectal cancer.Methods The literature related to TCM syndromes of colorectal cancer was retrieved from CNKI,Wanfang Data,VIP and SinoMed.Information on syndrome types and symptoms was extracted to establish a traditional Chinese medicine syndrome database for colorectal cancer.Frequency statistics were used to analyze distribution of colorectal cancer syndrome types and their symptom characteristics.Lantern 5.0 software was used to establish a latent structure model based on the LTM-EAS algorithm,and factor analysis and systematic clustering analysis were conducted using SPSS 27.0 software to infer potential patterns.Based on the results of comprehensive frequency statistics,systematic clustering and latent structure analysis,common TCM syndrome types and symptom characteristics of colorectal cancer were obtained.Results A total of 929 articles were included,totaling 2 465 syndrome items,involving 97 syndrome types,with high frequency of qi-blood deficiency syndrome,dampness and heat accumulation syndrome,spleen-kidney yang deficiency syndrome,etc.,and 281 symptoms,including abdominal distension,anorexia,abdominal pain and mental fatigue,etc.The latent structure analysis obtained 23 hidden variables,and 8 common syndromes were obtained according to professional knowledge.Factor analysis obtained 17 common factors,and further systematic cluster analysis inferred 9 potential syndrome types.Conclusion Common syndrome of colorectal cancer can be divided into 9 types,which are dampness and heat accumulation syndrome,blood stasis toxicity internal obstruction syndrome,qi stagnation and blood stasis syndrome,dampness and heat stasis toxicity syndrome,spleen deficiency and phlegm-dampness syndrome,spleen qi deficiency syndrome,qi and blood deficiency syndrome,liver-kidney yin deficiency syndrome,and spleen-kidney yang deficiency syndrome.The symptom characteristics of each syndrome are significant,which can provide reference for clinical differentiation and lay foundation for standardized research on syndrome.关键词
结直肠癌/中医证候/文献研究/隐结构/系统聚类Key words
colorectal cancer/TCM syndrome/literature research/latent structure/systematic clustering分类
医药卫生引用本文复制引用
赵硕琪,姚源,孙晓荷,李柳,程海波..基于隐结构模型和聚类分析的结直肠癌常见中医证候研究[J].中国中医药信息杂志,2025,32(4):51-57,7.基金项目
国家重点研发计划"中医药现代化"重点专项(2022YFC3500200、2022YFC3500204) （2022YFC3500200、2022YFC3500204）
国家中医药管理局中医药创新团队及人才支持计划项目(ZYYCXTD-C-202208) （ZYYCXTD-C-202208）
国家中医药管理局高水平中医药重点学科建设项目(2023年) （2023年）
江苏高校优势学科建设工程资助项目-中医学、中西医结合(PAPD) （PAPD）
江苏高校"青蓝工程"资助项目(2023年) （2023年）
