中国中医药信息杂志2025，Vol.32Issue(4)：58-64,7.DOI:10.19879/j.cnki.1005-5304.202408089
手法治疗膝骨关节炎随机对照试验的结局指标现状分析
Analysis on the Current Status of Outcome Indicators in Randomized Controlled Trials of Manual Treatment for Knee Osteoarthritis
摘要
Abstract
Objective To provide suggestions for the clinical efficacy evaluation method of manual therapy for knee osteoarthritis(KOA)by analyzing the current status of the use of outcome indicators in randomized controlled trials(RCTs)of manual therapy for KOA.Methods RCTs about manual treatment of KOA were retrieved from CNKI,Wanfang Data,VIP,SinoMed,PubMed,Cochrane Library,Scopus and Web of Science from March 2014 to March 2024.Two researchers screened literature,extracted literature features,analyzed the RCT indicator domain,measurement tools,and measurement time points for manual treatment of KOA.Results A total of 134 articles were included,with a sample size of 17 659.A total of 138 outcome indicators were used to classify the outcome indicators:64 symptoms and signs(46.4%),54 physical and chemical examinations(39.1%),11 quality of life(8.0%),2 psychological status indicators(1.4%),2 safety indicators(1.4%),2 muscle strength testing indicators(1.4%)and 3 other indicators(2.2%).Among 134 articles,there were a total of 36 measurement time points,with a research time span of 1 hour to 1 year after treatment;91 articles(67.9%)used"clinical efficacy"as the outcome measure;27 articles(20.1%)were evaluated for safety and reported adverse events.Conclusion The RCT outcome indicators of manual therapy for KOA lack representativeness,integrality,objectivity and specificity.The rigorism of the outcome indicators should be improved from the aspects of representativeness,integrality,objectivity and specificity,in order to achieve a complete evaluation effect on disease research.关键词
膝骨关节炎/推拿/随机对照试验/结局指标Key words
knee osteoarthritis/tuina/randomized controlled trials/outcome indicators分类
医药卫生引用本文复制引用
顾金光,魏光成,赵勇,董永丽,卓泽川,侯成志,秦伟凯..手法治疗膝骨关节炎随机对照试验的结局指标现状分析[J].中国中医药信息杂志,2025,32(4):58-64,7.基金项目
中国中医科学院科技创新工程(CI2021A03604) （CI2021A03604）
中国中医科学院望京医院高水平中医医院建设项目"名老医药专家学术经验传承"(WJCC-202316) （WJCC-202316）
