中国全科医学2025，Vol.28Issue(20)：2481-2490,10.DOI:10.12114/j.issn.1007-9572.2024.0669
昼夜节律综合征和代谢综合征对主、客观认知功能的影响:基于平阴队列的横断面研究
The Impact of Circadian Syndrome and Metabolic Syndrome on Subjective and Objective Cognitive Functions:a Cross-sectional Analysis from the Pingyin Cohort
摘要
Abstract
Background Current studies on the association between metabolic syndrome(MetS)and cognitive function remain inconsistent,and research exploring circadian rhythm syndrome(CircS)and subjective cognitive function are lacking.Objective To analyze the effects of CircS and MetS on both subjective and objective cognitive functions,providing theoretical support for the early prevention and intervention of cognitive decline and dementia.Methods This study conducted a cross-sectional study based on the Pingyin cohort data.Launched in July 2023 in Pingyin County,Shandong Province,the Pingyin Cohort Study employed a multi-stage cluster random sampling method,selecting permanent residents aged 45-70 years from seven villages of three towns as the research population.MetS was defined by harmonized criteria,while CircS included MetS components combined with short sleep duration and depression.Multivariate linear regression models were used to analyze the associations of CircS and MetS with subjective and objective cognitive scores,while multivariate Logistic regression analysis was employed to investigate their effects on abnormalities in these scores.Results A total of 2 187 people were surveyed at baseline and 2 165 valid samples were obtained.This study utilized baseline survey data,excluding individuals with missing CircS diagnostic data and covariates,resulting in a final inclusion of 1 939 participants.The prevalence of MetS and CircS was 48.2%(934/1 939)and 31.5%(611/1 939),respectively.Specifically,356(18.4%)had MetS alone,33(1.7%)had CircS alone,and 578(29.8%)had both.Multivariate linear regression analysis revealed that,compared with healthy individuals,women with MetS alone had lower SCD-Q9 scores(β=-0.487,95%CI=-0.875 to-0.099),whereas men with MetS alone had higher MoCA-B scores(β=1.097,95%CI=0.261-1.934).In contrast,the overall population with CircS alone had elevated SCD-Q9 scores(β=1.643,95%CI=0.765-2.521),and men with CircS alone displayed markedly reduced MoCA-B scores(β=-3.644,95%CI=-6.323 to-0.965).Multivariable Logistic regression analysis demonstrated that,compared to healthy individuals,men and women with CircS alone exhibited 10.46-fold(95%CI=1.87-196.20)and 5.11-fold(95%CI=1.85-18.03)higher odds of abnormal SCD-Q9 scores,respectively,whereas those with MetS alone showed lower risks(men:OR=0.62,95%CI=0.40-0.97;women:OR=0.65,95%CI=0.47-0.91).Short sleep duration was associated with abnormal SCD-Q9 scores(OR=1.79,95%CI=1.44-2.22),while depressive symptoms were linked to both abnormal SCD-Q9 scores(OR=4.75,95%CI=3.41-6.72)and MoCA-B scores(OR=1.48,95%CI=1.06-2.08).Conclusion Patients with CircS demonstrate significant cognitive impairment,while MetS patients without short sleep or depression exhibit better cognitive function.CircS may serve as a robust predictor of subjective cognitive decline in middle-aged and elderly Chinese populations.关键词
昼夜节律综合征/代谢综合征/主观认知功能/客观认知功能/横断面研究Key words
Circadian syndrome/Metabolic syndrome/Subjective cognitive function/Objective cognitive function/Cross-sectional study分类
临床医学引用本文复制引用
张露艺,于瑞洪,王琪,张小宇,李响,王仲璇,朱东山..昼夜节律综合征和代谢综合征对主、客观认知功能的影响:基于平阴队列的横断面研究[J].中国全科医学,2025,28(20):2481-2490,10.基金项目
国家自然科学基金资助项目(82273702) （82273702）
山东省优秀青年科学基金项目(海外)(2022HWYQ-030) （海外）
泰山学者项目专项基金(tsqnz20221103) （tsqnz20221103）
