中国药房2025，Vol.36Issue(9)：1147-1152,6.DOI:10.6039/j.issn.1001-0408.2025.09.22
姜黄素抗抑郁作用机制的研究进展
Research progress on mechanism of antidepressant action of curcumin
摘要
Abstract
Curcumin is a natural yellow pigment,a natural phenolic antioxidant extracted from the rhizomes of Curcuma longa and Curcumae Rhizoma of the ginger family,with anti-inflammatory,anti-tumor and antioxidant properties.In recent years,it has been found that curcumin also has good antidepressant properties,and it is considered a safe and effective antidepressant potential drug.The mechanism of curcumin's antidepressant efficacy mainly includes regulating neurotransmitters,modulating the hypothalamic-pituitary-adrenal axis,regulating brain-derived neurotrophic factor,inhibiting neuroinflammation,inhibiting oxidative stress,and regulating gut microbiota,etc.,and there is an overlapping and synergistic therapeutic effect of the above mechanisms.At present,the antidepressant mechanism of curcumin is still not fully understood,and will be combined with multi-omics technology,new formulation technology,and clinical trials to obtain further breakthroughs in the future.关键词
姜黄素/抑郁症/神经递质/炎症反应/氧化应激/作用机制Key words
curcumin/depression/neurotransmitter/inflammatory response/oxidative stress/mechanism分类
医药卫生引用本文复制引用
周建平,席雨婷,付皓,周策..姜黄素抗抑郁作用机制的研究进展[J].中国药房,2025,36(9):1147-1152,6.基金项目
国家自然科学基金(青年科学基金)项目(No.82305250) （青年科学基金）
四川省自然科学基金项目(No.2022NSFSC1418) （No.2022NSFSC1418）
