中国医院用药评价与分析2025，Vol.25Issue(4)：385-388,393,5.DOI:10.14009/j.issn.1672-2124.2025.04.001
基于国家专利的中药复方治疗三叉神经痛的数据挖掘研究
Data Mining on Traditional Chinese Medicine Compound Formulated from National Patents in the Treatment of Trigeminal Neuralgia
摘要
Abstract
OBJECTIVE:To analyze the medication patterns of traditional Chinese medicine compound patents in the treatment of trigeminal neuralgia,so as to provide reference for the research and development of new prescriptions.METHODS:Prescription data of traditional Chinese medicine for trigeminal neuralgia in the national patent database were retrieved(search time was from database establishment to Sept.30th,2024),and Excel 2021 was used to perform statistics on flavors and frequency,R 4.3.3 software was used for the analysis of association rules,clustering,and correlation coefficients.The core complex network of traditional Chinese medicine was constructed by Cytoscape 3.8,and the dense clusters of traditional Chinese medicine were extracted.RESULTS:A total of 171 patents were enrolled,including 609 flavors of medicines.The top 4 high-frequency medicines were Chuanxiong rhizoma,licorice,Buthus martensi,and Radix angelicae dahuricae.The medicinal properties were mainly cold,followed by warm.The medicinal flavors were bitter,followed by pungent and sweet.The top 3 meridians were liver meridian,lung meridian,and stomach meridian.The commonly used pairs of drugs were Radix angelicae dahuricae-Chuanxiong rhizoma,Scolopendra subspinipes mutilans-Buthus martensi,Bombyx Batryticatus-Buthus martensi,with the combinations including Radix angelicae dahuricae-Buthus martensi-Chuanxiong rhizoma,licorice,Scolopendra subspinipes mutilans-Chuanxiong rhizoma-Buthus martensi,Bombyx Batryticatus-Buthus martensi-Chuanxiong rhizoma.Four groups of core drug combinations were extracted by complex cluster analysis,and two potential drug combinations were identified.CONCLUSIONS:Traditional Chinese medicine compound patents in the treatment of trigeminal neuralgia are based on dispelling wind and relieving pain as the basic rule of treatment.The medication patterns and potential drug combinations obtained can lay a foundation for guiding clinical drug use and new drug development.关键词
三叉神经痛/中药复方专利/数据挖掘/R语言/组方规律Key words
Trigeminal neuralgia/Traditional Chinese medicine compound patents/Data mining/R language/Formulation patterns分类
药学引用本文复制引用
李相国,黄德斌,杨柳..基于国家专利的中药复方治疗三叉神经痛的数据挖掘研究[J].中国医院用药评价与分析,2025,25(4):385-388,393,5.基金项目
国家自然科学基金资助项目(No.82060745) （No.82060745）
河南省中医药青苗人才项目(No.豫卫中医药科教[2024]4号) （No.豫卫中医药科教[2024]4号）
洛阳市中医脑病重点实验室(No.洛市科[2023]70号) （No.洛市科[2023]70号）
