中国医院用药评价与分析2025，Vol.25Issue(4)：389-393,5.DOI:10.14009/j.issn.1672-2124.2025.04.002
药物治疗管理对慢性肾脏病患者依从性、疗效的影响研究
Effects of Medication Therapy Management on Compliance and Efficacy in Patients with Chronic Kidney Disease
摘要
Abstract
OBJECTIVE:To probe into the effects of medication therapy management(MTM)services on medication compliance,drug-related problems(DRPs)and efficacy in patients with chronic kidney disease(CKD),and to assess the clinical applicability.METHODS:A total of 130 CKD patients hospitalized in the Nephrology and Rheumatology Department of the hospital from Jun.2022 to Jun.2024 were enrolled and assigned into the MTM service group(n=65)and the control group(n=65)according to the random number table method.The control group received standard chronic disease management,while the MTM service group was given systematic MTM service led by clinical pharmacists based on the control group.Morisky Medication Adherence Scale(MMAS-8)score,DRPs occurrence,length of stay,blood pressure control,glycated hemoglobin(HbA1c)compliance rate and glomerular filtration rate(eGFR)of two groups were observed and compared during hospitalization and follow-up,and statistical analysis was performed.RESULTS:After 3 and 6 months of intervention,the proportion of patients with poor compliance in the MTM service group decreased significantly,and the difference was statistically significant compared with the control group(P<0.05).Compared with before intervention,MMAS-8 scores of patients in the MTM service group increased significantly after 1,3 and 6 months of intervention,with statistically significant differences(P<0.001).The number of patients with DRPs was lower in the MTM service group than those in the control group(P=0.021),especially in the primary domain of drug use process(P=0.034),with statistically significant differences.The length of stay in the MTM service group was shorter than that in the control group(median:7 d vs.9 d,P=0.002),the difference was statistically significant.The blood pressure compliance rate and HbA1c compliance rate of patients in MTM service group were higher than those in control group(P<0.05),and the proportion of patients with eGFR decreased by≥25%was lower than that in control group(P=0.027),the differences were statistically significant.CONCLUSIONS:MTM services provided by clinical pharmacists can improve medication compliance in CKD patients,reduce the occurrence of DRPs,shorten length of stay,and have positive effects on blood pressure,HbA1c compliance rate and eGFR protection.关键词
药物治疗管理/慢性肾病/用药依从性/疗效Key words
Medication therapy management/Chronic kidney disease/Medication compliance/Efficacy分类
药学引用本文复制引用
陈骁,沈正泽..药物治疗管理对慢性肾脏病患者依从性、疗效的影响研究[J].中国医院用药评价与分析,2025,25(4):389-393,5.基金项目
重庆市科卫联合医学科研项目(No.2022MSXM047) （No.2022MSXM047）
重庆医科大学未来医学青年创新团队支持计划(No.W0067) （No.W0067）
