中国医院用药评价与分析2025，Vol.25Issue(4)：394-398,402,6.DOI:10.14009/j.issn.1672-2124.2025.04.003
基于化学表征评价的泽泻汤传统汤剂与中药配方颗粒汤剂的差异性研究
Differences Between Traditional Zexie Decoction and Traditional Chinese Medicine Formula Granules Decoction Based on Chemical Characterization Evaluation
摘要
Abstract
OBJECTIVE:Based on chemical characterization evaluation,to probe into the differences between traditional Zexie decoction and traditional Chinese medicine formula granules decoction,so as to provide references for rational application of traditional Chinese medicine formula granules decoction in clinic.METHODS:Chemical characterizations such as extract yield rate,content of indicative components,similarity of specific chromatogram and total area of common peaks were used as inspection indicators to analyze the pharmacological differences between traditional Zexie decoction and traditional Chinese medicine formula granules decoction.RESULTS:In terms of the extract yield rate,the ratio of extract yield rate between traditional Zexie decoction and traditional Chinese medicine formula granules decoction was 0.77 to 0.84,in terms of the content of indicative components,the contents of atractylenolide Ⅲ and alisol C 23-acetate in traditional Chinese medicine formula granules decoction were lower than those in traditional Zexie decoction,with statistically significant differences(P<0.05),while the differences in atractylenolide Ⅱ and alisol B 23-acetate between traditional Chinese medicine formula granules decoction and traditional Zexie decoction were not statistically significant(P>0.05).In terms of the mean value of total content of indicative components,the ratio between traditional decoction and traditional Chinese medicine formula granules decoction was 0.76.In terms of the similarity of specific chromatogram,the similarity between the control spectra generated by traditional decoction and traditional Chinese medicine formula granules decoction was>90%.In terms of the areas of common peaks,there was statistically significant difference in the components of traditional Chinese medicine formula granules decoction from different manufacturers,the ratio of the mean value of the total area of common peaks between traditional decoction and traditional Chinese medicine formula granules decoction was 0.69.CONCLUSIONS:The similarity of specific chromatogram indicates that there is consistency between traditional Chinese medicine formula granules decoction and traditional decoction of Zexie decoction.Results of extract yield rate,content of indicative components and total area of common peaks indicates that the decoction effect of traditional decoction is only 69%to 84%of traditional Chinese medicine formula granules decoction.It is suggested that the dosage should be appropriately reduced when taking traditional Chinese medicine formula granules decoction.关键词
泽泻汤/化学表征/出膏率/指标性成分/特征图谱/配方颗粒Key words
Zexie decoction/Chemical characterization/Extract yield rate/Indicative components/Specific chromatogram/Formulated granules分类
药学引用本文复制引用
李旨君,刘海彬,张艳,吕依妍,冷怡林,郭媛媛,李佳怡,曹俊岭..基于化学表征评价的泽泻汤传统汤剂与中药配方颗粒汤剂的差异性研究[J].中国医院用药评价与分析,2025,25(4):394-398,402,6.基金项目
河南省中医药科学研究重大专项课题(No.2023ZYZD14) （No.2023ZYZD14）
曹俊岭全国老药工传承工作室建设项目(No.国中医药人教函[2024]255号) （No.国中医药人教函[2024]255号）
河南省临床中药学中医药重点学科建设项目(No.豫卫中医药科教[2024]1号) （No.豫卫中医药科教[2024]1号）
