中国医院用药评价与分析2025，Vol.25Issue(4)：403-406,4.DOI:10.14009/j.issn.1672-2124.2025.04.005
ABCB1 C3435T基因多态性对阿托伐他汀降低维吾尔族冠心病患者三酰甘油水平的影响
Effects of ABCB1 C3435T Gene Polymorphism on Reduction of Triglyceride Levels by Atorvastatin in Uygur Patients with Coronary Heart Disease
摘要
Abstract
OBJECTIVE:To analyze the effects of ABCB1 C3435T gene polymorphism on reduction of triglyceride(TG)levels by atorvastatin in Uygur patients with coronary heart disease(CHD).METHODS:A total of 193 Uygur patients initially diagnosed with CHD in the hospital from Apr.5th,2017 to Dec.11th,2023 were selected.The enrolled patients were respectively given atorvastatin 20 mg once a day or 40 mg once a day for 8 weeks.The TG levels of patients before and after atorvastatin administration were determined separately,and ABCB1 C3435T genotype was determined by fluorescent staining in situ hybridization.Factors influencing the percentage changes of TG levels were analyzed.RESULTS:A total of 193 Uygur patients were enrolled,compared with the baseline,the atorvastatin treatment had significantly reduced TG levels of patients,with statistically significant difference(P<0.05).Multi-factor Logistic regression analysis showed that baseline TG level(β=0.204,95%CI=1.980-10.493,P=0.004)and ABCB1 C3435T gene TT type(β=0.162,95%CI=2.517-23.406,P=0.023)were correlated with the reduction of TG levels in patients received atorvastatin.CONCLUSIONS:ABCB1 C3435T genotype polymorphism is an influencing factor in the reduction of TG levels by atorvastatin in Uyghur CHD patients.This study can provide effective basis for individualized lipid-regulating therapy for Uyghur CHD patients.关键词
ABCB1 C3435T基因多态性/阿托伐他汀/三酰甘油/维吾尔族/冠心病Key words
ABCB1 C3435T gene polymorphisms/Atorvastatin/Triglyceride/Uygur/Coronary heart disease分类
医药卫生引用本文复制引用
沈皓,王婷婷,李红健,于鲁海,孙力..ABCB1 C3435T基因多态性对阿托伐他汀降低维吾尔族冠心病患者三酰甘油水平的影响[J].中国医院用药评价与分析,2025,25(4):403-406,4.基金项目
新疆维吾尔自治区自然科学基金面上项目(No.2023D01C68) （No.2023D01C68）
新疆维吾尔自治区自然科学基金青年项目(No.2022D01C839) （No.2022D01C839）
